Vol 57, No 1 (2006)
Original paper
Published online: 2006-03-20
Correlation between thyroid stimulating immunoglobulins and thyrotropin binding inhibitory immunoglobulins levels in patients with Graves’ disease
Endokrynol Pol 2006;57(1):23-30.
Abstract
Introduction: The II generation method using human recombination
thyrotropin receptors for measurement of thyrotropin
binding inhibitory immunoglobulins (TBII) is characterized
by increased sensitivity and specificity in comparison
with I generation method.
Aim of study was to determine, whether TBII levels measured
with II generation assay reflect thyroid stimulation
and whether measurement of thyroid stimulating antibodies
(TSI) could be replaced by TBII determinations. Specific
aim was to evaluate, whether correlation between TSI
and TBII levels is stable during antithyroid therapy.
Material and methods: 41 patients with the newly diagnosed Graves’ disease were included in the study. TSI (cAMP levels in CHO cell line) and TBII (II generation assay) levels were determined before treatment and after 1, 3, 6, 9 and 12 months of thiamazol therapy. Moreover, thyroid blocking antibodies were determined after 12 months of treatment.
Results: 32 patients (82.05%) had positive basic TSI level and 35 patients (89.74%) had positive basic TBII level. After 12 months of therapy negative level of TSI was observed in 67.57% of patients and negative level of TBII was founded in 45.85% of patients. Correlation between TSI and TBII levels was positive during treatment course except time after 9 months of therapy.
Conclusions: TBII level is adequate parameter to assess thyroid stimulation intensity. Positive correlation between TSI and TBII levels is present during almost whole treatment course. TBII seems to be reliable parameter in disease activity monitoring and response to therapy.
Material and methods: 41 patients with the newly diagnosed Graves’ disease were included in the study. TSI (cAMP levels in CHO cell line) and TBII (II generation assay) levels were determined before treatment and after 1, 3, 6, 9 and 12 months of thiamazol therapy. Moreover, thyroid blocking antibodies were determined after 12 months of treatment.
Results: 32 patients (82.05%) had positive basic TSI level and 35 patients (89.74%) had positive basic TBII level. After 12 months of therapy negative level of TSI was observed in 67.57% of patients and negative level of TBII was founded in 45.85% of patients. Correlation between TSI and TBII levels was positive during treatment course except time after 9 months of therapy.
Conclusions: TBII level is adequate parameter to assess thyroid stimulation intensity. Positive correlation between TSI and TBII levels is present during almost whole treatment course. TBII seems to be reliable parameter in disease activity monitoring and response to therapy.
Keywords: Graves’ diseasestimulating antibodiesTSH receptorepitopes
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