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open access

Vol 57, No 2 (2006)
Review article
Published online: 2006-05-26
Submitted: 2013-02-15
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Current knowledge on aquaporin water channels: clinical implications

Małgorzata Jasiewicz, Janusz Myśliwiec
Endokrynologia Polska 2006;57(2):149-157.

open access

Vol 57, No 2 (2006)
Review article
Published online: 2006-05-26
Submitted: 2013-02-15

Abstract

The discovery of the aquaporin family of water channels has explained to a high degree the mechanism of water transport across cell membranes. The molecular structure of the first purified aquaporin shows its tetrameric organization with each subunit containing an individual aqueous pore selectively permeable for water but not for protons. At least 11 human aquaporins have been identified. Definition of sites of their expression enabled explanation of their physiological role as well as pathological importance in congenital cataract or nephrogenic diabetes insipidus.

Abstract

The discovery of the aquaporin family of water channels has explained to a high degree the mechanism of water transport across cell membranes. The molecular structure of the first purified aquaporin shows its tetrameric organization with each subunit containing an individual aqueous pore selectively permeable for water but not for protons. At least 11 human aquaporins have been identified. Definition of sites of their expression enabled explanation of their physiological role as well as pathological importance in congenital cataract or nephrogenic diabetes insipidus.

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Keywords

aquaporins; congenital cataract; diabetes insipidus

About this article
Title

Current knowledge on aquaporin water channels: clinical implications

Journal

Endokrynologia Polska

Issue

Vol 57, No 2 (2006)

Pages

149-157

Published online

2006-05-26

Bibliographic record

Endokrynologia Polska 2006;57(2):149-157.

Keywords

aquaporins
congenital cataract
diabetes insipidus

Authors

Małgorzata Jasiewicz
Janusz Myśliwiec

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