Thyroid hormones and the cardiomyocytes

Aleksander Gatnar; Bogdan Marek; Dorota Pakuła; Dariusz Kajdaniuk; Beata Kos-Kudła; Halina Borgiel-Marek; Roman Gnot; Piotr Pakuła; Magdalena Pawłowska

Vol 57, No 2 (2006)

Review paper

Submitted: 2013-02-15

Published online: 2006-05-26

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Thyroid hormones and the cardiomyocytes

Aleksander Gatnar, Bogdan Marek, Dorota Pakuła, Dariusz Kajdaniuk, Beata Kos-Kudła, Halina Borgiel-Marek, Roman Gnot, Piotr Pakuła, Magdalena Pawłowska

Endokrynol Pol 2006;57(2):144-148.

Vol 57, No 2 (2006)

Review Article

Submitted: 2013-02-15

Published online: 2006-05-26

Abstract

The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its influence on the expression of cardiomyocyte genes. These genes encode both structural and regulatory proteins in the heart (myosin heavy chains, sarcoplasmic reticulum calcium-activated ATP-ase, phospholamban). The impaired myocardium contractile activity in hypothyreosis reminds findings in heart failure and may warrant further exploration of therapeutic approaches using thyroid hormone to improve cardiac function in heart failure.