open access

Vol 57, No 2 (2006)
Review article
Published online: 2006-05-26
Submitted: 2013-02-15
Get Citation

Thyroid hormones and the cardiomyocytes

Aleksander Gatnar, Bogdan Marek, Dorota Pakuła, Dariusz Kajdaniuk, Beata Kos-Kudła, Halina Borgiel-Marek, Roman Gnot, Piotr Pakuła, Magdalena Pawłowska
Endokrynologia Polska 2006;57(2):144-148.

open access

Vol 57, No 2 (2006)
Review article
Published online: 2006-05-26
Submitted: 2013-02-15

Abstract

The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its influence on the expression of cardiomyocyte genes. These genes encode both structural and regulatory proteins in the heart (myosin heavy chains, sarcoplasmic reticulum calcium-activated ATP-ase, phospholamban). The impaired myocardium contractile activity in hypothyreosis reminds findings in heart failure and may warrant further exploration of therapeutic approaches using thyroid hormone to improve cardiac function in heart failure.

Abstract

The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its influence on the expression of cardiomyocyte genes. These genes encode both structural and regulatory proteins in the heart (myosin heavy chains, sarcoplasmic reticulum calcium-activated ATP-ase, phospholamban). The impaired myocardium contractile activity in hypothyreosis reminds findings in heart failure and may warrant further exploration of therapeutic approaches using thyroid hormone to improve cardiac function in heart failure.
Get Citation

Keywords

thyroid hormone; cardiomyocyte; contractility; heart failure

About this article
Title

Thyroid hormones and the cardiomyocytes

Journal

Endokrynologia Polska

Issue

Vol 57, No 2 (2006)

Pages

144-148

Published online

2006-05-26

Bibliographic record

Endokrynologia Polska 2006;57(2):144-148.

Keywords

thyroid hormone
cardiomyocyte
contractility
heart failure

Authors

Aleksander Gatnar
Bogdan Marek
Dorota Pakuła
Dariusz Kajdaniuk
Beata Kos-Kudła
Halina Borgiel-Marek
Roman Gnot
Piotr Pakuła
Magdalena Pawłowska

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