open access

Vol 57, No 2 (2006)
Original papers
Published online: 2006-05-26
Submitted: 2013-02-15
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Analysis of adrenocortical tumours morphology as regards their structure and potential malignancy

Maciej Kajor, Jacek Ziaja, Robert Król, Monika Ciupińska-Kajor, Zuzanna Dobrosz, Marek Heitzman, Lech Cierpka
Endokrynologia Polska 2006;57(2):136-142.

open access

Vol 57, No 2 (2006)
Original papers
Published online: 2006-05-26
Submitted: 2013-02-15

Abstract

Introduction: A consequence of diagnosis of adrenocortical carcinoma (ACC) is introduction of pharmacological therapy, precise monitoring of the patients and in some cases re-operation. The aim of the study is to analyse morphology of adrenocortical tumours as regards their malignancy by use of criteria proposed by Weiss.
Material and methods: 110 adrenocortical tumours in 107 patients were analysed (M 27.1%, F 72.9%; age 32 to 77 years, mean 55.2 ± 9.7). Conn syndrome was diagnosed in 16 patients (14.9%), Cushing syndrome in 12 (11.2%), and virilisation in 3 (2.8%). In 76 patients (71.0%) biochemical tests did not reveal hormonal hyperactivity of the tumour.
Results 5/50 high power fields in 6 (5.4%), atypical mitoses in 5 (4.5%), clear cells constituting < 25% of the tumour in 10 (9.1%), diffuse architecture in 8 (7.3%), necrosis in 16 (14.5%), veins infiltration in 4 (3.6%), sinusoids infiltration in 7 (6.3%), and tumour capsule infiltration in 5 (4.5%). Among ACC tumours 4-9 features of malignancy were present, among ACA - 0-3 features. Statistical analysis revealed correlation between number of criteria proposed by Weiss and maximal tumour size (p < 0.05).
Conclusion: The structure and cell arrangement in adrenocortical adenoma are heterogeneous. Application of criteria proposed by Weiss in histopathological examination of adrenocortical tumours can be useful in differentiating adrenocortical adenoma from carcinoma.

Abstract

Introduction: A consequence of diagnosis of adrenocortical carcinoma (ACC) is introduction of pharmacological therapy, precise monitoring of the patients and in some cases re-operation. The aim of the study is to analyse morphology of adrenocortical tumours as regards their malignancy by use of criteria proposed by Weiss.
Material and methods: 110 adrenocortical tumours in 107 patients were analysed (M 27.1%, F 72.9%; age 32 to 77 years, mean 55.2 &plusmn; 9.7). Conn syndrome was diagnosed in 16 patients (14.9%), Cushing syndrome in 12 (11.2%), and virilisation in 3 (2.8%). In 76 patients (71.0%) biochemical tests did not reveal hormonal hyperactivity of the tumour.
Results 5/50 high power fields in 6 (5.4%), atypical mitoses in 5 (4.5%), clear cells constituting < 25% of the tumour in 10 (9.1%), diffuse architecture in 8 (7.3%), necrosis in 16 (14.5%), veins infiltration in 4 (3.6%), sinusoids infiltration in 7 (6.3%), and tumour capsule infiltration in 5 (4.5%). Among ACC tumours 4-9 features of malignancy were present, among ACA - 0-3 features. Statistical analysis revealed correlation between number of criteria proposed by Weiss and maximal tumour size (p < 0.05).
Conclusion: The structure and cell arrangement in adrenocortical adenoma are heterogeneous. Application of criteria proposed by Weiss in histopathological examination of adrenocortical tumours can be useful in differentiating adrenocortical adenoma from carcinoma.
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Keywords

adrenal cortex; adrenocortical carcinoma; adrenocortical adenoma; adrenocortical hyperplasia

About this article
Title

Analysis of adrenocortical tumours morphology as regards their structure and potential malignancy

Journal

Endokrynologia Polska

Issue

Vol 57, No 2 (2006)

Pages

136-142

Published online

2006-05-26

Bibliographic record

Endokrynologia Polska 2006;57(2):136-142.

Keywords

adrenal cortex
adrenocortical carcinoma
adrenocortical adenoma
adrenocortical hyperplasia

Authors

Maciej Kajor
Jacek Ziaja
Robert Król
Monika Ciupińska-Kajor
Zuzanna Dobrosz
Marek Heitzman
Lech Cierpka

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