open access

Vol 57, No 2 (2006)
Original papers
Published online: 2006-05-26
Submitted: 2013-02-15
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The effect of weight loss on serum concentration of interleukine-6 (IL-6) and insulin resistance

Magdalena Olszanecka-Glinianowicz, Barbara Zahorska-Markiewicz, Piotr Kocełak, Joanna Janowska, Michał Holecki, Elżbieta Semik-Grabarczyk
Endokrynologia Polska 2006;57(2):131-135.

open access

Vol 57, No 2 (2006)
Original papers
Published online: 2006-05-26
Submitted: 2013-02-15

Abstract

Introduction: Interleukine-6 (IL-6) is one of the cytokines, excreting by adipocytes, which increases in obesity. These cytokines participate in very complicated mechanisms of developing insulin resistance that accompany obesity. The aim of the study was to:
1) evaluate the influence of weight loss on insulin resistance and serum concentration of IL-6,
2) evaluate the hypothetical association between serum concentration of IL-6 and the improvement of insulin sensitivity in obese women after weight loss.
Material and methods: The study involved 27 obese women (age 40.3 ± 11.1 year; BMI 37.4 ± 5.2 kg/m2) with insulin resistance diagnosed using HOMA index, without concomitant diseases and without any medication. All the patients participated in complex weight reduction treatment (diet, physical activity and psychotherapy). Before and after weight reduction therapy weight and height were measured, body composition was determined using bioimpedance analysis. Serum concentration of glucose was determined by enzymatic procedure, serum concentration of insulin was measured by radioimmunoassay, serum concentration of IL-6 was measured by ELISA. HOMA index was calculated with formula. Results: The mean weight loss after 3-month was 9.2 ± 4.5 kg (approximately 10% of initial weight). After weight reduction significant decreases in HOMA index, insulin and IL-6 concentrations was observed. However, no correlations between changes in insulin concentrations, HOMA index and decrease of IL-6 concentration were showed. We observed significant correlations between ΔHOMA and ΔBMI (r = 0.48; p = 0.012) and Δ percentage fat mass (r = 0.39; p < 0.05).
Conclusions: A moderate weight loss improves insulin sensitivity and decreases serum concentrations of IL-6. However improvement of insulin sensitivity is the effect of fat mass reduction and does not change serum concentration of IL-6.

Abstract

Introduction: Interleukine-6 (IL-6) is one of the cytokines, excreting by adipocytes, which increases in obesity. These cytokines participate in very complicated mechanisms of developing insulin resistance that accompany obesity. The aim of the study was to:
1) evaluate the influence of weight loss on insulin resistance and serum concentration of IL-6,
2) evaluate the hypothetical association between serum concentration of IL-6 and the improvement of insulin sensitivity in obese women after weight loss.
Material and methods: The study involved 27 obese women (age 40.3 ± 11.1 year; BMI 37.4 ± 5.2 kg/m2) with insulin resistance diagnosed using HOMA index, without concomitant diseases and without any medication. All the patients participated in complex weight reduction treatment (diet, physical activity and psychotherapy). Before and after weight reduction therapy weight and height were measured, body composition was determined using bioimpedance analysis. Serum concentration of glucose was determined by enzymatic procedure, serum concentration of insulin was measured by radioimmunoassay, serum concentration of IL-6 was measured by ELISA. HOMA index was calculated with formula. Results: The mean weight loss after 3-month was 9.2 ± 4.5 kg (approximately 10% of initial weight). After weight reduction significant decreases in HOMA index, insulin and IL-6 concentrations was observed. However, no correlations between changes in insulin concentrations, HOMA index and decrease of IL-6 concentration were showed. We observed significant correlations between ΔHOMA and ΔBMI (r = 0.48; p = 0.012) and Δ percentage fat mass (r = 0.39; p < 0.05).
Conclusions: A moderate weight loss improves insulin sensitivity and decreases serum concentrations of IL-6. However improvement of insulin sensitivity is the effect of fat mass reduction and does not change serum concentration of IL-6.
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Keywords

interleukine-6; insulin resistance; weight loss

About this article
Title

The effect of weight loss on serum concentration of interleukine-6 (IL-6) and insulin resistance

Journal

Endokrynologia Polska

Issue

Vol 57, No 2 (2006)

Pages

131-135

Published online

2006-05-26

Bibliographic record

Endokrynologia Polska 2006;57(2):131-135.

Keywords

interleukine-6
insulin resistance
weight loss

Authors

Magdalena Olszanecka-Glinianowicz
Barbara Zahorska-Markiewicz
Piotr Kocełak
Joanna Janowska
Michał Holecki
Elżbieta Semik-Grabarczyk

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