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Pattern visual evoked potentials in the early diagnosis of optic neuropathy in the course of Graves’ ophthalmopathy
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Abstract
Material and methods. Two groups of patients were examined: 15 patients with GO without clinical signs of dysthyroid optic neuropathy (DON) and 12 healthy controls. The correlations between the N75 and P100 latencies, IOP and Hertel exophthalmometry were investigated.
Results. The mean PVEP N75 and P100 latencies were significantly delayed in the GO uncomplicated with DON in comparison with controls (LP100- 106.2 ± 4.4 ms vs. 102.4 ± 2.7 ms, p < 0.01 and LN75- 79.0 ± 3.7 ms vs. 73.9 ± 2.8 ms, p < 0.001). In GO patients we documented a positive correlation between the LN75 latency and exophthalmometric readings (R = 0.51; p < 0.01). The value of LP100 and LN75 was above the normal limit in 5/30 eyes (17%) and in 3/30 eyes (10%) respectively.
Conclusions: The assessment of PVEPs (especially the P100 latency) in GO patients without clinical signs of DON is a useful tool for the early diagnosis of optic nerve involvement.
Abstract
Material and methods. Two groups of patients were examined: 15 patients with GO without clinical signs of dysthyroid optic neuropathy (DON) and 12 healthy controls. The correlations between the N75 and P100 latencies, IOP and Hertel exophthalmometry were investigated.
Results. The mean PVEP N75 and P100 latencies were significantly delayed in the GO uncomplicated with DON in comparison with controls (LP100- 106.2 ± 4.4 ms vs. 102.4 ± 2.7 ms, p < 0.01 and LN75- 79.0 ± 3.7 ms vs. 73.9 ± 2.8 ms, p < 0.001). In GO patients we documented a positive correlation between the LN75 latency and exophthalmometric readings (R = 0.51; p < 0.01). The value of LP100 and LN75 was above the normal limit in 5/30 eyes (17%) and in 3/30 eyes (10%) respectively.
Conclusions: The assessment of PVEPs (especially the P100 latency) in GO patients without clinical signs of DON is a useful tool for the early diagnosis of optic nerve involvement.
Keywords
subclinical optic neuropathy; Graves’ ophthalmopathy; pattern visual evoked potentials
About this articleTitle
Pattern visual evoked potentials in the early diagnosis of optic neuropathy in the course of Graves’ ophthalmopathy
Journal
Issue
Article type
Original paper
Pages
122-126
Published online
2006-05-26
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Bibliographic record
Endokrynol Pol 2006;57(2):122-126.
Keywords
subclinical optic neuropathy
Graves’ ophthalmopathy
pattern visual evoked potentials
Authors
Przemysław Pawłowski
Janusz Myśliwiec
Małgorzata Mrugacz
Alina Bakunowicz-Łazarczyk
Maria Górska
