open access

Vol 57, No 2 (2006)
Original papers
Published online: 2006-05-26
Submitted: 2013-02-15
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Evaluation of low density lipoprotein oxidation in a course of hypothyroidism

Magdalena Lampka, Roman Junik, Anna Nowicka, Hanna Kardymowicz, Piotr Kaczorowski, Tomasz Tyrakowski
Endokrynologia Polska 2006;57(2):116-121.

open access

Vol 57, No 2 (2006)
Original papers
Published online: 2006-05-26
Submitted: 2013-02-15

Abstract

Introduction: The aim of this study was to evaluate the influence of hypothyroidism on oxidative modification of low density lipoprotein (LDL).
Material and methods: 24 patients with overt hypothyroidism and 10 patients with mild hypothyroidism were enrolled to the study. The control group consisted of 24 healthy subjects with normal serum TSH. Plasma level of oxidized LDL (oxLDL) and serum level of antibodies against oxidized LDL (anti-oxLDL) determined lipoprotein oxidation.
Results: Significantly increased plasma oxLDL levels were found in patients with overt hypothyroidism in comparison to patients with mild hypothyroidism and control group. Anti-oxLDL levels in patients with overt or mild hypothyroidism and in the control group showed no significant differences. OxLDL plasma levels in patients with hypothyroidism inversely correlated with FT4 levels and positively correlated with TSH, total cholesterol, LDL cholesterol and triglycerides levels.
Conclusions: The presented study indicates increased lipoprotein oxidation in patients with hypothyroidism which depends on the degree of hypothyroidism and changes in lipid profile. Elevated cholesterol and triglicerides levels are the factors increasing lipoprotein oxidation. Plasma oxLDL levels may constitute a useful marker indicating the risk for atherosclerosis in hypothyroidism.

Abstract

Introduction: The aim of this study was to evaluate the influence of hypothyroidism on oxidative modification of low density lipoprotein (LDL).
Material and methods: 24 patients with overt hypothyroidism and 10 patients with mild hypothyroidism were enrolled to the study. The control group consisted of 24 healthy subjects with normal serum TSH. Plasma level of oxidized LDL (oxLDL) and serum level of antibodies against oxidized LDL (anti-oxLDL) determined lipoprotein oxidation.
Results: Significantly increased plasma oxLDL levels were found in patients with overt hypothyroidism in comparison to patients with mild hypothyroidism and control group. Anti-oxLDL levels in patients with overt or mild hypothyroidism and in the control group showed no significant differences. OxLDL plasma levels in patients with hypothyroidism inversely correlated with FT4 levels and positively correlated with TSH, total cholesterol, LDL cholesterol and triglycerides levels.
Conclusions: The presented study indicates increased lipoprotein oxidation in patients with hypothyroidism which depends on the degree of hypothyroidism and changes in lipid profile. Elevated cholesterol and triglicerides levels are the factors increasing lipoprotein oxidation. Plasma oxLDL levels may constitute a useful marker indicating the risk for atherosclerosis in hypothyroidism.
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Keywords

hypothyroidism; lipoprotein oxidation; oxidized LDL; antibodies against oxidized LDL

About this article
Title

Evaluation of low density lipoprotein oxidation in a course of hypothyroidism

Journal

Endokrynologia Polska

Issue

Vol 57, No 2 (2006)

Pages

116-121

Published online

2006-05-26

Bibliographic record

Endokrynologia Polska 2006;57(2):116-121.

Keywords

hypothyroidism
lipoprotein oxidation
oxidized LDL
antibodies against oxidized LDL

Authors

Magdalena Lampka
Roman Junik
Anna Nowicka
Hanna Kardymowicz
Piotr Kaczorowski
Tomasz Tyrakowski

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