Vol 57, No 2 (2006)
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Published online: 2006-05-26

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Evaluation of low density lipoprotein oxidation in a course of hypothyroidism

Magdalena Lampka, Roman Junik, Anna Nowicka, Hanna Kardymowicz, Piotr Kaczorowski, Tomasz Tyrakowski
Endokrynol Pol 2006;57(2):116-121.


Introduction: The aim of this study was to evaluate the influence of hypothyroidism on oxidative modification of low density lipoprotein (LDL).
Material and methods: 24 patients with overt hypothyroidism and 10 patients with mild hypothyroidism were enrolled to the study. The control group consisted of 24 healthy subjects with normal serum TSH. Plasma level of oxidized LDL (oxLDL) and serum level of antibodies against oxidized LDL (anti-oxLDL) determined lipoprotein oxidation.
Results: Significantly increased plasma oxLDL levels were found in patients with overt hypothyroidism in comparison to patients with mild hypothyroidism and control group. Anti-oxLDL levels in patients with overt or mild hypothyroidism and in the control group showed no significant differences. OxLDL plasma levels in patients with hypothyroidism inversely correlated with FT4 levels and positively correlated with TSH, total cholesterol, LDL cholesterol and triglycerides levels.
Conclusions: The presented study indicates increased lipoprotein oxidation in patients with hypothyroidism which depends on the degree of hypothyroidism and changes in lipid profile. Elevated cholesterol and triglicerides levels are the factors increasing lipoprotein oxidation. Plasma oxLDL levels may constitute a useful marker indicating the risk for atherosclerosis in hypothyroidism.

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