Vol 57, No 3 (2006)
Review paper
Submitted: 2013-02-15
Published online: 2006-06-28
The incidence of somatostatin receptors in human neoplasms in the light of ex vivo–in vitro studies
Marek Pawlikowski
Endokrynol Pol 2006;57(3):238-243.
Vol 57, No 3 (2006)
Review Article
Submitted: 2013-02-15
Published online: 2006-06-28
Abstract
Human neoplastic cells express and often even over-express
the somatostatin receptors (sstr). It concerns not only pituitary
tumors and the so-called neuroendocrine tumors of
the gut, but many other neoplasms, including the non-endocrine
cancers. The incidence of sstr is important because
it determinates the possibility of treatment with SST (somatostatin)
analogs. The examination of sstr is possible under
the in vivo conditions, by means of the receptor scintigraphy
using the radiolabeled SST analogs. The receptors can
be also examined under the ex vivo–in vitro conditions,
using the post-surgical or biopsy specimens. Among the in
vitro (ex vivo) methods, the immunohistochemical investigation
with specific anti-receptor antibodies seems to be
particularly useful for routine clinical diagnostics. This review
presents the data, obtained by means of different in
vitro techniques, on the incidence of five sstr subtypes in the different human tumors, deriving from endocrine
glands, diffuse neuroendocrine cells as well as in neoplasms
consididered as non-endocrine.
Abstract
Human neoplastic cells express and often even over-express
the somatostatin receptors (sstr). It concerns not only pituitary
tumors and the so-called neuroendocrine tumors of
the gut, but many other neoplasms, including the non-endocrine
cancers. The incidence of sstr is important because
it determinates the possibility of treatment with SST (somatostatin)
analogs. The examination of sstr is possible under
the in vivo conditions, by means of the receptor scintigraphy
using the radiolabeled SST analogs. The receptors can
be also examined under the ex vivo–in vitro conditions,
using the post-surgical or biopsy specimens. Among the in
vitro (ex vivo) methods, the immunohistochemical investigation
with specific anti-receptor antibodies seems to be
particularly useful for routine clinical diagnostics. This review
presents the data, obtained by means of different in
vitro techniques, on the incidence of five sstr subtypes in the different human tumors, deriving from endocrine
glands, diffuse neuroendocrine cells as well as in neoplasms
consididered as non-endocrine.
Keywords
neoplasms; somatostatin receptors; immunohistochemistry
Title
The incidence of somatostatin receptors in human neoplasms in the light of ex vivo–in vitro studies
Journal
Endokrynologia Polska
Issue
Vol 57, No 3 (2006)
Article type
Review paper
Pages
238-243
Published online
2006-06-28
Page views
451
Article views/downloads
1323
Bibliographic record
Endokrynol Pol 2006;57(3):238-243.
Keywords
neoplasms
somatostatin receptors
immunohistochemistry
Authors
Marek Pawlikowski
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