open access

Vol 57, No 3 (2006)
Review article
Published online: 2006-06-28
Submitted: 2013-02-15
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The incidence of somatostatin receptors in human neoplasms in the light of ex vivo–in vitro studies

Marek Pawlikowski
Endokrynologia Polska 2006;57(3):238-243.

open access

Vol 57, No 3 (2006)
Review article
Published online: 2006-06-28
Submitted: 2013-02-15

Abstract

Human neoplastic cells express and often even over-express the somatostatin receptors (sstr). It concerns not only pituitary tumors and the so-called neuroendocrine tumors of the gut, but many other neoplasms, including the non-endocrine cancers. The incidence of sstr is important because it determinates the possibility of treatment with SST (somatostatin) analogs. The examination of sstr is possible under the in vivo conditions, by means of the receptor scintigraphy using the radiolabeled SST analogs. The receptors can be also examined under the ex vivo–in vitro conditions, using the post-surgical or biopsy specimens. Among the in vitro (ex vivo) methods, the immunohistochemical investigation with specific anti-receptor antibodies seems to be particularly useful for routine clinical diagnostics. This review presents the data, obtained by means of different in vitro techniques, on the incidence of five sstr subtypes in the different human tumors, deriving from endocrine glands, diffuse neuroendocrine cells as well as in neoplasms consididered as non-endocrine.

Abstract

Human neoplastic cells express and often even over-express the somatostatin receptors (sstr). It concerns not only pituitary tumors and the so-called neuroendocrine tumors of the gut, but many other neoplasms, including the non-endocrine cancers. The incidence of sstr is important because it determinates the possibility of treatment with SST (somatostatin) analogs. The examination of sstr is possible under the in vivo conditions, by means of the receptor scintigraphy using the radiolabeled SST analogs. The receptors can be also examined under the ex vivo–in vitro conditions, using the post-surgical or biopsy specimens. Among the in vitro (ex vivo) methods, the immunohistochemical investigation with specific anti-receptor antibodies seems to be particularly useful for routine clinical diagnostics. This review presents the data, obtained by means of different in vitro techniques, on the incidence of five sstr subtypes in the different human tumors, deriving from endocrine glands, diffuse neuroendocrine cells as well as in neoplasms consididered as non-endocrine.
Get Citation

Keywords

neoplasms; somatostatin receptors; immunohistochemistry

About this article
Title

The incidence of somatostatin receptors in human neoplasms in the light of ex vivo–in vitro studies

Journal

Endokrynologia Polska

Issue

Vol 57, No 3 (2006)

Pages

238-243

Published online

2006-06-28

Bibliographic record

Endokrynologia Polska 2006;57(3):238-243.

Keywords

neoplasms
somatostatin receptors
immunohistochemistry

Authors

Marek Pawlikowski

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