open access

Vol 57, No 3 (2006)
Original papers
Published online: 2006-06-28
Submitted: 2013-02-15
Get Citation

Triiodothyronine receptors (TR) are present in breast cancer tissues

Marcin Dębski, Lucyna Dębska, Ewa Bar-Andziak
Endokrynologia Polska 2006;57(3):223-229.

open access

Vol 57, No 3 (2006)
Original papers
Published online: 2006-06-28
Submitted: 2013-02-15

Abstract

Introduction: Possible relationships between breast cancer and thyroid hormones have been suggested for many years. The aim of this study was qualitative examination of triiodothyronine receptors (TR) in breast cancer tissues and in non cancerous breast tissue taken from the opposite side to the localization of the tumor.
Material and methods: The material consisted of 15 breast cancer tissues of grades G1 to G3 and the same number of control tissues obtained during radical mastectomy or local tumor resection. Tissues were homogenized. Protein fraction was isolated. Protein for TR was assessed in Western Blot reaction.
Results: Protein fraction for TR was present in all cancer tissues and 6 healthy controls.
Conclusions: Obtained data may suggest so far unknown role of thyroid hormones and their nuclear receptors in the generation and development of breast cancer.

Abstract

Introduction: Possible relationships between breast cancer and thyroid hormones have been suggested for many years. The aim of this study was qualitative examination of triiodothyronine receptors (TR) in breast cancer tissues and in non cancerous breast tissue taken from the opposite side to the localization of the tumor.
Material and methods: The material consisted of 15 breast cancer tissues of grades G1 to G3 and the same number of control tissues obtained during radical mastectomy or local tumor resection. Tissues were homogenized. Protein fraction was isolated. Protein for TR was assessed in Western Blot reaction.
Results: Protein fraction for TR was present in all cancer tissues and 6 healthy controls.
Conclusions: Obtained data may suggest so far unknown role of thyroid hormones and their nuclear receptors in the generation and development of breast cancer.
Get Citation

Keywords

breast cancer; triiodothyronine receptors; thyroid hormones

About this article
Title

Triiodothyronine receptors (TR) are present in breast cancer tissues

Journal

Endokrynologia Polska

Issue

Vol 57, No 3 (2006)

Pages

223-229

Published online

2006-06-28

Bibliographic record

Endokrynologia Polska 2006;57(3):223-229.

Keywords

breast cancer
triiodothyronine receptors
thyroid hormones

Authors

Marcin Dębski
Lucyna Dębska
Ewa Bar-Andziak

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl