open access

Vol 57, No 3 (2006)
Original papers
Published online: 2006-06-28
Submitted: 2013-02-15
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Oxidative stress markers during a course of hyperthyroidism

Magdalena Lampka, Roman Junik, Anna Nowicka, Ewa Kopczyńska, Tomasz Tyrakowski, Grażyna Odrowąż-Sypniewska
Endokrynologia Polska 2006;57(3):218-222.

open access

Vol 57, No 3 (2006)
Original papers
Published online: 2006-06-28
Submitted: 2013-02-15

Abstract

Introduction: Previous studies have shown the presence of oxidative stress in hyperthyroid patients. The aim of this study was to evaluate the influence of hyperthyroidism on lipid peroxidation, plasma lipoprotein oxidation and antioxidant status. We have estimated the clinical utility of the biochemical parameters analysed as markers of oxidative stress in hyperthyroidism.
Material and methods: Twenty five patients with overt hyperthyroidism because of Graves’ disease or toxic multinodular goitre and 20 healthy subjects were included in the study. Lipid peroxidation was evaluated by measurement of peroxides and malondialdehyde with 4-hydroxynonenal (MDA + 4-HNE) concentrations. Autoantibodies against oxidised LDL (anti-oxLDL) were assayed as a marker of lipoprotein oxidation. Changes in the antioxidant defence system were estimated by measurement of total antioxidant status in serum (TAS) and erythrocyte superoxide dismutase activity (SOD).
Results: A significant increase in serum concentration of peroxides and MDA + 4-HNE was observed in patients with hyperthyroidism. However, no difference was found in anti-oxLDL concentration and antioxidant status parameters (TAS, SOD) between the control group and the patient group.
Conclusions: Our results indicate an intensification of the oxidative processes caused by an excess of thyroid hormones, which is not accompanied by a response from the antioxidant system. Elevated concentrations of lipid peroxidation products in serum, both peroxides and malondialdehyde with 4-hydroxynonenal, may be useful as markers of oxidative stress during the course of hyperthyroidism.

Abstract

Introduction: Previous studies have shown the presence of oxidative stress in hyperthyroid patients. The aim of this study was to evaluate the influence of hyperthyroidism on lipid peroxidation, plasma lipoprotein oxidation and antioxidant status. We have estimated the clinical utility of the biochemical parameters analysed as markers of oxidative stress in hyperthyroidism.
Material and methods: Twenty five patients with overt hyperthyroidism because of Graves’ disease or toxic multinodular goitre and 20 healthy subjects were included in the study. Lipid peroxidation was evaluated by measurement of peroxides and malondialdehyde with 4-hydroxynonenal (MDA + 4-HNE) concentrations. Autoantibodies against oxidised LDL (anti-oxLDL) were assayed as a marker of lipoprotein oxidation. Changes in the antioxidant defence system were estimated by measurement of total antioxidant status in serum (TAS) and erythrocyte superoxide dismutase activity (SOD).
Results: A significant increase in serum concentration of peroxides and MDA + 4-HNE was observed in patients with hyperthyroidism. However, no difference was found in anti-oxLDL concentration and antioxidant status parameters (TAS, SOD) between the control group and the patient group.
Conclusions: Our results indicate an intensification of the oxidative processes caused by an excess of thyroid hormones, which is not accompanied by a response from the antioxidant system. Elevated concentrations of lipid peroxidation products in serum, both peroxides and malondialdehyde with 4-hydroxynonenal, may be useful as markers of oxidative stress during the course of hyperthyroidism.
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Keywords

hyperthyroidism; oxidative stress; lipid peroxidation; LDL oxidation; autoantibodies

About this article
Title

Oxidative stress markers during a course of hyperthyroidism

Journal

Endokrynologia Polska

Issue

Vol 57, No 3 (2006)

Pages

218-222

Published online

2006-06-28

Bibliographic record

Endokrynologia Polska 2006;57(3):218-222.

Keywords

hyperthyroidism
oxidative stress
lipid peroxidation
LDL oxidation
autoantibodies

Authors

Magdalena Lampka
Roman Junik
Anna Nowicka
Ewa Kopczyńska
Tomasz Tyrakowski
Grażyna Odrowąż-Sypniewska

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