open access

Vol 57, No 3 (2006)
Original papers
Published online: 2006-06-28
Submitted: 2013-02-15
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Selected markers of endothelial dysfunction in patients with subclinical and overt hyperthyroidism

Anna Modzelewska, Małgorzata Szelachowska, Anna Zonenberg, Saeid Abdelrazek, Agnieszka Nikołajuk, Maria Górska
Endokrynologia Polska 2006;57(3):202-209.

open access

Vol 57, No 3 (2006)
Original papers
Published online: 2006-06-28
Submitted: 2013-02-15

Abstract

Introduction: There are many factors causing endothelial dysfunction. The aim was to observe chosen markers of endothelial function in patients with subclinical and overt hyperthyroidism.
Material and methods: We studied 97 patients with hyperthyroidism: 51 with subclinical (44 F/7 M; mean age 49.3 ± 15.9 y) and 46 patients with overt (39 F/7 M, mean age 50.4 ± 13.2 y). The control comprised of 39 healthy volunteers (26 F/13 M, mean age 47.5 ± 11.8 y). Concentration of TSH, FT3, FT4 were measured by MEIA, TPO Ab, TG Ab, E-selectin, interleukin 6, VCAM-1, ICAM-1 by ELISA.
Results: The goiter was found in 71 persons 63F/8M, mean age 49.9 ± 15.3 y, (42-subclinical, 29-overt). Morbus Graves-Basedow was diagnosed in 26 persons, 20 F/6 M, mean age 49.5 ± 12.8 y (9-subclinical, 17-overt). There were no significant differences serum concentration of E-selectin, IL-6, ICAM-1 in patients with subclinical and overt hyperthyroidism compared to the control. Statistically significant differences were shown between concentration of IL-6 in patients with Graves-Basedow compared with the control (p < 0.05). Significance of VCAM-1 values were found in the patients with subclinical and overt hyperthyroidism compared to the control (p < 0.001; p < 0.001, respectively).
Conclusions: Among persons with overt and subclinical hyperthyroidism occurs endothelial dysfunction which doesn’t depends on exciting cause of thyrotoxicosis but on degree of hyperthyroidism. Elevated concentrations of endothelial markers may confirm that persons with thyroid disorders are extremely exposed to the occurrence of the cardiovascular diseases.

Abstract

Introduction: There are many factors causing endothelial dysfunction. The aim was to observe chosen markers of endothelial function in patients with subclinical and overt hyperthyroidism.
Material and methods: We studied 97 patients with hyperthyroidism: 51 with subclinical (44 F/7 M; mean age 49.3 ± 15.9 y) and 46 patients with overt (39 F/7 M, mean age 50.4 ± 13.2 y). The control comprised of 39 healthy volunteers (26 F/13 M, mean age 47.5 ± 11.8 y). Concentration of TSH, FT3, FT4 were measured by MEIA, TPO Ab, TG Ab, E-selectin, interleukin 6, VCAM-1, ICAM-1 by ELISA.
Results: The goiter was found in 71 persons 63F/8M, mean age 49.9 ± 15.3 y, (42-subclinical, 29-overt). Morbus Graves-Basedow was diagnosed in 26 persons, 20 F/6 M, mean age 49.5 ± 12.8 y (9-subclinical, 17-overt). There were no significant differences serum concentration of E-selectin, IL-6, ICAM-1 in patients with subclinical and overt hyperthyroidism compared to the control. Statistically significant differences were shown between concentration of IL-6 in patients with Graves-Basedow compared with the control (p < 0.05). Significance of VCAM-1 values were found in the patients with subclinical and overt hyperthyroidism compared to the control (p < 0.001; p < 0.001, respectively).
Conclusions: Among persons with overt and subclinical hyperthyroidism occurs endothelial dysfunction which doesn’t depends on exciting cause of thyrotoxicosis but on degree of hyperthyroidism. Elevated concentrations of endothelial markers may confirm that persons with thyroid disorders are extremely exposed to the occurrence of the cardiovascular diseases.
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Keywords

overt and subclinical hyperthyroidism; endothelial dysfunction

About this article
Title

Selected markers of endothelial dysfunction in patients with subclinical and overt hyperthyroidism

Journal

Endokrynologia Polska

Issue

Vol 57, No 3 (2006)

Pages

202-209

Published online

2006-06-28

Bibliographic record

Endokrynologia Polska 2006;57(3):202-209.

Keywords

overt and subclinical hyperthyroidism
endothelial dysfunction

Authors

Anna Modzelewska
Małgorzata Szelachowska
Anna Zonenberg
Saeid Abdelrazek
Agnieszka Nikołajuk
Maria Górska

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