Vol 57, No 4 (2006)
Original paper
Published online: 2006-07-07
Evaluation of p53 and soluble Fas ligand (sFasL) serum level concentration as indicators of apoptosis in serum of patients with benign and malignant primary follicular thyroid tumors
Endokrynol Pol 2006;57(4):320-325.
Abstract
Introduction: Apoptosis (programmed cell death) is the best
described mode of physiological cell death. During embryonal
development and morphogenesis, apoptosis may be
induced by two pathways. The first is external protein signal
originating from other cell - also named as "death
signal". Another one is specific cell reaction for external
stress factors. Blood concentration of proteins regulating
both pathways of apoptosis may be useful in early diagnosis
and staging of thyroid tumors. The aim of study was evaluation
of p53 and sFasL blood concentration in patients with
benign follicular adenoma and follicular thyroid cancer.
Materials and methods: The study population was composed of 28 patients: 14 with thyroid carcinoma and 14 patients with follicular neoplasm (NF). All patients underwent surgical treatment. P53 and sFasL levels were evaluated before surgery and related to the histopathological diagnosis obtained post-surgery.
Results: The analysis revealed high sFasL blood concentration in patients with follicular thyroid cancer in comparison with the group with follicular adenoma. There was no statistically significant difference between levels of p53 in both groups.
Conclusions: Evaluation of sFasL serum level concentration may be useful in preoperative diagnosis of follicular thyroid tumors.
Materials and methods: The study population was composed of 28 patients: 14 with thyroid carcinoma and 14 patients with follicular neoplasm (NF). All patients underwent surgical treatment. P53 and sFasL levels were evaluated before surgery and related to the histopathological diagnosis obtained post-surgery.
Results: The analysis revealed high sFasL blood concentration in patients with follicular thyroid cancer in comparison with the group with follicular adenoma. There was no statistically significant difference between levels of p53 in both groups.
Conclusions: Evaluation of sFasL serum level concentration may be useful in preoperative diagnosis of follicular thyroid tumors.
Keywords: apoptosisp53sFasLfollicular thyroid cancer
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