Vol 57, No 4 (2006)
Original paper
Published online: 2006-07-07
Comparison of CD15, galectin-3 and HBME-1 expression in follicular thyroid neoplasms
Endokrynol Pol 2006;57(4):314-319.
Abstract
Introduction: Estimation of malignancy in thyroid follicular
neoplasms is a common diagnostic problem, thus revealing
of differences in expression of some antigens in both
benign and malignant lesions seems to be essential. The aim
of this study is to evaluate the immunohistochemical expression
of CD15, galectin-3 and HBME-1 in follicular adenomas
and carcinomas.
Material and methods: Samples of 38 follicular adenomas (23 "classical", 5 with intracapsular invasion, 10 oncocytic) and 15 follicular carcinomas (9 "classic", 6 oncocytic) were stained immunohistochemically with anti-CD15, galectin-3 and HBME-1.
Results: In the whole group we found statistically significant differences in CD15 expression between follicular adenomas and carcinomas. "Classic" follicular carcinomas (without oncocytic tumors) showed stronger CD15 and HBME- 1 expression than "classic" adenomas. Adenomas with intracapsular invasion differed from "classic" adenomas only in HBME-1 expression. In oncocytic tumors the expression of examined antigens was similar.
Conclusions: 1. In the group of nonoxyphilic tumors positive reaction with HBME-1 was more common in adenomas with intracapsular invasion and carcinomas, but positive reaction with anti-CD15 - only in carcinomas. We suggest that reactivity with these antibodies could mark malignancy.
2. Oncocytic tumors had similar expression of CD15 and HBME-1 and galectin-3.
Material and methods: Samples of 38 follicular adenomas (23 "classical", 5 with intracapsular invasion, 10 oncocytic) and 15 follicular carcinomas (9 "classic", 6 oncocytic) were stained immunohistochemically with anti-CD15, galectin-3 and HBME-1.
Results: In the whole group we found statistically significant differences in CD15 expression between follicular adenomas and carcinomas. "Classic" follicular carcinomas (without oncocytic tumors) showed stronger CD15 and HBME- 1 expression than "classic" adenomas. Adenomas with intracapsular invasion differed from "classic" adenomas only in HBME-1 expression. In oncocytic tumors the expression of examined antigens was similar.
Conclusions: 1. In the group of nonoxyphilic tumors positive reaction with HBME-1 was more common in adenomas with intracapsular invasion and carcinomas, but positive reaction with anti-CD15 - only in carcinomas. We suggest that reactivity with these antibodies could mark malignancy.
2. Oncocytic tumors had similar expression of CD15 and HBME-1 and galectin-3.
Keywords: thyroid follicular carcinomathyroid follicular adenomaCD15galectin-3HBME-1
