Vol 57, No 4 (2006)
Original paper
Published online: 2006-07-07

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Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors

Waldemar Balcerzak, Wiktor Bednarz, Paweł Domosławski, Robert Olewiński, Justyna Kolesińska, Zbigniew Kamiński, Katarzyna Dziarkowska, Piotr Wieczorek
Endokrynol Pol 2006;57(4):307-313.


Introduction: Cancer of thyroid gland is the most common malignancy of the endocrine system. The treatment improvement could be achieved by early diagnosis. The aim of the study was to identify cancer specific antigenes with use of peptide libraries.
Material and methods: The material from 6 patients with thyroid cancer (4 with papillary cancer, 1 with follicular cancer and 1 with oxyphilic tumor) were analyzed. It was performed with use of lipophylic peptide libraries by direct comparison of staining of specimens prepared from normal and malignant tissue.
Results: Preliminary results confirm practical value of peptide libraries in early diagnostics of thyroid cancer.
Conclusions: It is important to optimize construction of peptide libraries by using different staining agents hydrolyzed by proteases.

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