open access

Vol 57, No 4 (2006)
Original papers
Published online: 2006-07-07
Submitted: 2013-02-15
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Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors

Waldemar Balcerzak, Wiktor Bednarz, Paweł Domosławski, Robert Olewiński, Justyna Kolesińska, Zbigniew Kamiński, Katarzyna Dziarkowska, Piotr Wieczorek
Endokrynologia Polska 2006;57(4):307-313.

open access

Vol 57, No 4 (2006)
Original papers
Published online: 2006-07-07
Submitted: 2013-02-15

Abstract

Introduction: Cancer of thyroid gland is the most common malignancy of the endocrine system. The treatment improvement could be achieved by early diagnosis. The aim of the study was to identify cancer specific antigenes with use of peptide libraries.
Material and methods: The material from 6 patients with thyroid cancer (4 with papillary cancer, 1 with follicular cancer and 1 with oxyphilic tumor) were analyzed. It was performed with use of lipophylic peptide libraries by direct comparison of staining of specimens prepared from normal and malignant tissue.
Results: Preliminary results confirm practical value of peptide libraries in early diagnostics of thyroid cancer.
Conclusions: It is important to optimize construction of peptide libraries by using different staining agents hydrolyzed by proteases.

Abstract

Introduction: Cancer of thyroid gland is the most common malignancy of the endocrine system. The treatment improvement could be achieved by early diagnosis. The aim of the study was to identify cancer specific antigenes with use of peptide libraries.
Material and methods: The material from 6 patients with thyroid cancer (4 with papillary cancer, 1 with follicular cancer and 1 with oxyphilic tumor) were analyzed. It was performed with use of lipophylic peptide libraries by direct comparison of staining of specimens prepared from normal and malignant tissue.
Results: Preliminary results confirm practical value of peptide libraries in early diagnostics of thyroid cancer.
Conclusions: It is important to optimize construction of peptide libraries by using different staining agents hydrolyzed by proteases.
Get Citation

Keywords

thyroid gland; papillary thyroid cancer; medullary thyroid cancer; neoplasma folliculare; diagnostic tool

About this article
Title

Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors

Journal

Endokrynologia Polska

Issue

Vol 57, No 4 (2006)

Pages

307-313

Published online

2006-07-07

Bibliographic record

Endokrynologia Polska 2006;57(4):307-313.

Keywords

thyroid gland
papillary thyroid cancer
medullary thyroid cancer
neoplasma folliculare
diagnostic tool

Authors

Waldemar Balcerzak
Wiktor Bednarz
Paweł Domosławski
Robert Olewiński
Justyna Kolesińska
Zbigniew Kamiński
Katarzyna Dziarkowska
Piotr Wieczorek

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