Vol 57, No 5 (2006)
Case report
Published online: 2006-11-06
Graves-Basedow disease after allogeneic bone marrow transplantation
Endokrynol Pol 2006;57(5):541-543.
Abstract
One severe aplastic anaemia case who presented autoimmune
thyroid disease after allogeneic bone marrow transplantation
(alloBMT) is described. A 19 year old Polish girl
developed Graves’ hyperthyroidisms 19 months after allogeneic
BMT for severe aplastic anaemia
(SAA) donated from her brother. Her serum was positive
for thyroid stimulating antibody
(TSAb) and anti-thyroid peroxidase autoantibodies
(aTPO) while her brother remained euthyroid, seronegative
for TSAb, and showed no clinical signs of thyroid
pathology. The genetic studies of lymphocytes FISH
(fluorescence in situ hybridization) and analysis of STR
(short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor
origin.
Keywords: Graves-Basedow diseaseallogenic bone marrow transplantationantithyroid peroxidase autoantibodythyroid stimulating antibody
