Graves-Basedow disease after allogeneic bone marrow transplantation

Beata Jakubas; Marta Kostecka-Matyja; Andrzej Darczuk; Justyna Gil

Vol 57, No 5 (2006)

Case report

Submitted: 2013-02-15

Published online: 2006-11-06

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Graves-Basedow disease after allogeneic bone marrow transplantation

Beata Jakubas, Marta Kostecka-Matyja, Andrzej Darczuk, Justyna Gil

Endokrynol Pol 2006;57(5):541-543.

Vol 57, No 5 (2006)

Case report

Submitted: 2013-02-15

Published online: 2006-11-06

Abstract

One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves’ hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive for thyroid stimulating antibody (TSAb) and anti-thyroid peroxidase autoantibodies (aTPO) while her brother remained euthyroid, seronegative for TSAb, and showed no clinical signs of thyroid pathology. The genetic studies of lymphocytes FISH (fluorescence in situ hybridization) and analysis of STR (short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor origin.