open access

Vol 57, No 5 (2006)
Case report
Published online: 2006-11-06
Submitted: 2013-02-15
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Graves-Basedow disease after allogeneic bone marrow transplantation

Beata Jakubas, Marta Kostecka-Matyja, Andrzej Darczuk, Justyna Gil
Endokrynologia Polska 2006;57(5):541-543.

open access

Vol 57, No 5 (2006)
Case report
Published online: 2006-11-06
Submitted: 2013-02-15

Abstract

One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves’ hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive for thyroid stimulating antibody (TSAb) and anti-thyroid peroxidase autoantibodies (aTPO) while her brother remained euthyroid, seronegative for TSAb, and showed no clinical signs of thyroid pathology. The genetic studies of lymphocytes FISH (fluorescence in situ hybridization) and analysis of STR (short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor origin.

Abstract

One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves’ hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive for thyroid stimulating antibody (TSAb) and anti-thyroid peroxidase autoantibodies (aTPO) while her brother remained euthyroid, seronegative for TSAb, and showed no clinical signs of thyroid pathology. The genetic studies of lymphocytes FISH (fluorescence in situ hybridization) and analysis of STR (short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor origin.
Get Citation

Keywords

Graves-Basedow disease; allogenic bone marrow transplantation; antithyroid peroxidase autoantibody; thyroid stimulating antibody

About this article
Title

Graves-Basedow disease after allogeneic bone marrow transplantation

Journal

Endokrynologia Polska

Issue

Vol 57, No 5 (2006)

Pages

541-543

Published online

2006-11-06

Bibliographic record

Endokrynologia Polska 2006;57(5):541-543.

Keywords

Graves-Basedow disease
allogenic bone marrow transplantation
antithyroid peroxidase autoantibody
thyroid stimulating antibody

Authors

Beata Jakubas
Marta Kostecka-Matyja
Andrzej Darczuk
Justyna Gil

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