Vol 57, No 6 (2006)
Review paper
Published online: 2006-11-29
The adiponectin role in pathogenesis of metabolic syndrome and cardiovascular disease
Endokrynol Pol 2006;57(6):626-632.
Abstract
The aim of this review is to present the up-to-date data about
adiponectin and it’s role in pathogenesis of cardiovascular
disease. Adiponectin is a hormone derived from adipose
tissue which regulates energy metabolism, and plays an
important role in the pathogenesis of insulin resistance.
Serum levels of adiponectin are reduced in obesity, hypertension,
metabolic syndrome and type 2 diabetes. Moreover,
plasma adiponectin concentration is inversely associated
with LDL-cholesterol, TG and is positively related to HDLcholesterol.
Recent studies have indicated that adiponectin
has antiinflammatory and antiatherogenic properties. Review
of the data confirmed the hypothesis that adiponectin plays an important role in pathogenesis of cardiovascular
disease.
Keywords: adiponectinmetabolic syndromecardiovascular disease
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