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The effect of levothyroxine on the proliferative activity of the thyroid follicular cells
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Abstract
Material and methods: Cytological material was obtained from 32 euthyroid females, aged 34-69 years, by USG-guided Fine-Needle Aspiration Biopsy (FNAB), before and after 6 months treatment with levothyroxine. The patients were divided into 2 age groups: up to 45 years (14 patients) and above 45 years (18 females). Proliferative activity of the follicular cells was assessed by the proliferative index (PI), representing the percentage of follicular cells with positive reaction with the antibody Ki-67. Microscopic evaluation was carried out using morphometric computer system MicroImage InCD UDF (Olympus).
Results: After 6-months of treatment IP values decreased significantly in both groups studied (8.59 ± 3.07 vs 6.51 ± ± 1.91; p < 0.001 in females aged < 45 years and 7.72 ± 1.83 vs 5.09 ± 1.51; p < 0.001 in the older group).
Conclusion: Our results indicate that levothyroxine has an influence on the proliferative activity of the thyroid follicular cells, particularly in post-menopausal women.
Abstract
Material and methods: Cytological material was obtained from 32 euthyroid females, aged 34-69 years, by USG-guided Fine-Needle Aspiration Biopsy (FNAB), before and after 6 months treatment with levothyroxine. The patients were divided into 2 age groups: up to 45 years (14 patients) and above 45 years (18 females). Proliferative activity of the follicular cells was assessed by the proliferative index (PI), representing the percentage of follicular cells with positive reaction with the antibody Ki-67. Microscopic evaluation was carried out using morphometric computer system MicroImage InCD UDF (Olympus).
Results: After 6-months of treatment IP values decreased significantly in both groups studied (8.59 ± 3.07 vs 6.51 ± ± 1.91; p < 0.001 in females aged < 45 years and 7.72 ± 1.83 vs 5.09 ± 1.51; p < 0.001 in the older group).
Conclusion: Our results indicate that levothyroxine has an influence on the proliferative activity of the thyroid follicular cells, particularly in post-menopausal women.
Keywords
nodular non-toxic goitre; follicular cells; proliferative activity; Ki-67; levothyroxine
About this articleTitle
The effect of levothyroxine on the proliferative activity of the thyroid follicular cells
Journal
Issue
Article type
Original paper
Pages
52-58
Published online
2006-09-25
Page views
730
Article views/downloads
1091
Keywords
nodular non-toxic goitre
follicular cells
proliferative activity
Ki-67
levothyroxine
Authors
Janusz Dzięcioł
Anna Zonenberg
Beata Klim
Urszula Łebkowska
Anna Popławska
Dorota Lemancewicz
Piotr Kasprzyk
Katarzyna Ziętara
