open access
SNP polymorphism of LGALS3BP gene in patients with benign and malignant thyroid tumours
open access
Abstract
Material and methods: The studied group consisted of 58 patients, 24 with papillary thyroid carcinomas, 19 with nodular goiters and 15 with follicular adenomas. Control group included 180 healthy volunteers. Four different SNP polymorphisms were analysed in PCR products using the SNaPshot test, on genetic analyser ABI Prism 310; these can be found in NCBI database under rs numbers: 1803938 (a/g), 11024 (g/c), 1801463 (a/c) and 1131516 (c/t).
Results: In all patients analysis of SNP sites revealed: lack of polymorphism in a/g rs 18039380; polymorphism identical to database in g/c rs 11024 and polymorphism different from database in a/g rs 1801463 and c/g rs 131516. There were no significant differences between patients with thyroid lesions and group of healthy controls.
Conclusion: Single nucleotide polymorphism (SNP) of LGALS3BP gene (found in NCBI) database are not characteristic for papillary thyroid cancer, follicular adenomas and nodular goiter.
Abstract
Material and methods: The studied group consisted of 58 patients, 24 with papillary thyroid carcinomas, 19 with nodular goiters and 15 with follicular adenomas. Control group included 180 healthy volunteers. Four different SNP polymorphisms were analysed in PCR products using the SNaPshot test, on genetic analyser ABI Prism 310; these can be found in NCBI database under rs numbers: 1803938 (a/g), 11024 (g/c), 1801463 (a/c) and 1131516 (c/t).
Results: In all patients analysis of SNP sites revealed: lack of polymorphism in a/g rs 18039380; polymorphism identical to database in g/c rs 11024 and polymorphism different from database in a/g rs 1801463 and c/g rs 131516. There were no significant differences between patients with thyroid lesions and group of healthy controls.
Conclusion: Single nucleotide polymorphism (SNP) of LGALS3BP gene (found in NCBI) database are not characteristic for papillary thyroid cancer, follicular adenomas and nodular goiter.
Keywords
single nucleotide polymorphism (SNP); LGALS3BP gene; nodular goiter; follicular adenomas; thyroid cancer


Title
SNP polymorphism of LGALS3BP gene in patients with benign and malignant thyroid tumours
Journal
Issue
Article type
Original paper
Pages
45-52
Published online
2006-09-25
Page views
767
Article views/downloads
1128
Keywords
single nucleotide polymorphism (SNP)
LGALS3BP gene
nodular goiter
follicular adenomas
thyroid cancer
Authors
Tadeusz Łukieńczuk
Krzysztof Kaliszewski
Magdalena Żołędziewska
Anna Jonkisz
Grażyna Dmochowska
Mirosław Dobrut
Jacek Rogoliński
Tadeusz Dobosz