open access
Expression of DPP4 gene in papillary thyroid carcinoma
open access
Abstract
Material and methods: The analysis was carried out on total RNA extracted from 102 PTCs and 77 normal thyroid fragments with use of Q-PCR reaction. Beta-glucuronidase was the reference gene.
Results: We confirmed the distinct increase of DPP4 expression in papillary thyroid carcinoma. However, the ROC (relative operating characteristic) analysis revealed that the diagnostic efficiency of DPP4 estimation is limited.
Conclusions: DPP4 is increased in papillary thyroid cancer, however, its diagnostic usefulness as a single PTC marker is doubtful.
Abstract
Material and methods: The analysis was carried out on total RNA extracted from 102 PTCs and 77 normal thyroid fragments with use of Q-PCR reaction. Beta-glucuronidase was the reference gene.
Results: We confirmed the distinct increase of DPP4 expression in papillary thyroid carcinoma. However, the ROC (relative operating characteristic) analysis revealed that the diagnostic efficiency of DPP4 estimation is limited.
Conclusions: DPP4 is increased in papillary thyroid cancer, however, its diagnostic usefulness as a single PTC marker is doubtful.
Keywords
dipeptidyl peptidase IV; DPP4; papillary thyroid carcinoma; PTC; molecular markers; Q-PCR
Title
Expression of DPP4 gene in papillary thyroid carcinoma
Journal
Issue
Article type
Original paper
Pages
12-17
Published online
2006-09-25
Page views
784
Article views/downloads
1049
Keywords
dipeptidyl peptidase IV
DPP4
papillary thyroid carcinoma
PTC
molecular markers
Q-PCR
Authors
Joanna Ożóg
Michał Jarząb
Agnieszka Pawlaczek
Małgorzata Oczko-Wojciechowska
Jan Włoch
Józef Roskosz
Elżbieta Gubała