Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Endokrynologia Polska
MENU
Shortcuts Submit an article Author Guidelines Polish Society of Endocrinology Reviewers 2023 Redeem voucher

open access

Vol 58, No 1 (2007)
Review paper
Submitted: 2013-02-15
Published online: 2007-01-31
View PDF Download PDF file
Get Citation

Polypeptide growth factors in gastroenteropancreatic neuroendocrine tumours

Jolanta Blicharz-Dorniak, Beata Kos-Kudła, Marek Kudła, Wanda Foltyn, Bogdan Marek, Lucyna Siemińska, Mariusz Nowak
Endokrynol Pol 2007;58(1):42-51.

open access

Vol 58, No 1 (2007)
Review Article
Submitted: 2013-02-15
Published online: 2007-01-31

Abstract

Polypeptide growth factors form a potent class of extracellular signal molecules in the regulation of cellular differentiation and proliferation. Disturbances in the expression of growth factors influence the normal pathway of differentiation and lead to cellular transformation and tumour progression. Contemporary medical studies report that various growth factors such as those for platelet-derived growth factor, vascular endothelial growth factor, epidermal growth factor, hepatocyte growth factor and insulin-like growth factor are expressed in gastroenteropancreatic neuroendocrine tumours (GEP/NET). Polypeptide growth factors have great significance in the growth, progression and development of metastases by various tumours. We describe the role of growth factors in GEP/NET on the basis of the available reports of medical research.

Abstract

Polypeptide growth factors form a potent class of extracellular signal molecules in the regulation of cellular differentiation and proliferation. Disturbances in the expression of growth factors influence the normal pathway of differentiation and lead to cellular transformation and tumour progression. Contemporary medical studies report that various growth factors such as those for platelet-derived growth factor, vascular endothelial growth factor, epidermal growth factor, hepatocyte growth factor and insulin-like growth factor are expressed in gastroenteropancreatic neuroendocrine tumours (GEP/NET). Polypeptide growth factors have great significance in the growth, progression and development of metastases by various tumours. We describe the role of growth factors in GEP/NET on the basis of the available reports of medical research.

Full Text:

View PDF Download PDF file
Get Citation

Keywords

gastroenteropancreatic neuroendocrine tumours; growth factors; insulin-like growth factor; platelet-derived growth factor; vascular endothelial growth factor; epidermal growth factor; fibroblast growth factor

About this article
Title

Polypeptide growth factors in gastroenteropancreatic neuroendocrine tumours

Journal

Endokrynologia Polska

Issue

Vol 58, No 1 (2007)

Article type

Review paper

Pages

42-51

Published online

2007-01-31

Page views

651

Article views/downloads

1170

Bibliographic record

Endokrynol Pol 2007;58(1):42-51.

Keywords

gastroenteropancreatic neuroendocrine tumours
growth factors
insulin-like growth factor
platelet-derived growth factor
vascular endothelial growth factor
epidermal growth factor
fibroblast growth factor

Authors

Jolanta Blicharz-Dorniak
Beata Kos-Kudła
Marek Kudła
Wanda Foltyn
Bogdan Marek
Lucyna Siemińska
Mariusz Nowak

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą jest  VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl