Vol 58, No 1 (2007)
Review paper
Published online: 2007-01-31

open access

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Polypeptide growth factors in gastroenteropancreatic neuroendocrine tumours

Jolanta Blicharz-Dorniak, Beata Kos-Kudła, Marek Kudła, Wanda Foltyn, Bogdan Marek, Lucyna Siemińska, Mariusz Nowak
Endokrynol Pol 2007;58(1):42-51.


Polypeptide growth factors form a potent class of extracellular signal molecules in the regulation of cellular differentiation and proliferation. Disturbances in the expression of growth factors influence the normal pathway of differentiation and lead to cellular transformation and tumour progression. Contemporary medical studies report that various growth factors such as those for platelet-derived growth factor, vascular endothelial growth factor, epidermal growth factor, hepatocyte growth factor and insulin-like growth factor are expressed in gastroenteropancreatic neuroendocrine tumours (GEP/NET). Polypeptide growth factors have great significance in the growth, progression and development of metastases by various tumours. We describe the role of growth factors in GEP/NET on the basis of the available reports of medical research.

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