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Vol 58, No 1 (2007)
Review paper
Submitted: 2013-02-15
Published online: 2007-01-31
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Polypeptide growth factors in gastroenteropancreatic neuroendocrine tumours

Jolanta Blicharz-Dorniak, Beata Kos-Kudła, Marek Kudła, Wanda Foltyn, Bogdan Marek, Lucyna Siemińska, Mariusz Nowak
Endokrynol Pol 2007;58(1):42-51.

open access

Vol 58, No 1 (2007)
Review Article
Submitted: 2013-02-15
Published online: 2007-01-31

Abstract

Polypeptide growth factors form a potent class of extracellular signal molecules in the regulation of cellular differentiation and proliferation. Disturbances in the expression of growth factors influence the normal pathway of differentiation and lead to cellular transformation and tumour progression. Contemporary medical studies report that various growth factors such as those for platelet-derived growth factor, vascular endothelial growth factor, epidermal growth factor, hepatocyte growth factor and insulin-like growth factor are expressed in gastroenteropancreatic neuroendocrine tumours (GEP/NET). Polypeptide growth factors have great significance in the growth, progression and development of metastases by various tumours. We describe the role of growth factors in GEP/NET on the basis of the available reports of medical research.

Abstract

Polypeptide growth factors form a potent class of extracellular signal molecules in the regulation of cellular differentiation and proliferation. Disturbances in the expression of growth factors influence the normal pathway of differentiation and lead to cellular transformation and tumour progression. Contemporary medical studies report that various growth factors such as those for platelet-derived growth factor, vascular endothelial growth factor, epidermal growth factor, hepatocyte growth factor and insulin-like growth factor are expressed in gastroenteropancreatic neuroendocrine tumours (GEP/NET). Polypeptide growth factors have great significance in the growth, progression and development of metastases by various tumours. We describe the role of growth factors in GEP/NET on the basis of the available reports of medical research.

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Keywords

gastroenteropancreatic neuroendocrine tumours; growth factors; insulin-like growth factor; platelet-derived growth factor; vascular endothelial growth factor; epidermal growth factor; fibroblast growth factor

About this article
Title

Polypeptide growth factors in gastroenteropancreatic neuroendocrine tumours

Journal

Endokrynologia Polska

Issue

Vol 58, No 1 (2007)

Article type

Review paper

Pages

42-51

Published online

2007-01-31

Page views

605

Article views/downloads

1112

Bibliographic record

Endokrynol Pol 2007;58(1):42-51.

Keywords

gastroenteropancreatic neuroendocrine tumours
growth factors
insulin-like growth factor
platelet-derived growth factor
vascular endothelial growth factor
epidermal growth factor
fibroblast growth factor

Authors

Jolanta Blicharz-Dorniak
Beata Kos-Kudła
Marek Kudła
Wanda Foltyn
Bogdan Marek
Lucyna Siemińska
Mariusz Nowak

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