open access

Vol 58, No 1 (2007)
Original papers
Published online: 2007-01-31
Submitted: 2013-02-15
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Leptin promotes the growth of Colon 38 cancer cells and interferes with the cytotoxic effect of fluorouracil in vitro

Gabriela Mełeń-Mucha, Hanna Ławnicka
Endokrynologia Polska 2007;58(1):2-6.

open access

Vol 58, No 1 (2007)
Original papers
Published online: 2007-01-31
Submitted: 2013-02-15

Abstract


Introduction: Epidemiological studies underline the fact that obesity represents a significant risk factor for the development of several cancers, one of which is cancer of the colon. Moreover, multiple recent data indicate that some adipose tissue-derived hormones may influence the growth of malignant cells. Leptin, the product of the ob gene, is one of these. However, the evidence from research is still contradictory regarding the role of leptin in colon cancer. The aim of our study was to examine the direct effect of leptin at various concentrations (from 10-5 to 10-12 M) when applied alone or jointly with fluorouracil (the classical cytotoxic drug for colon cancer) at two concentrations (0.25 mg/ml and 2.5 mg/ml) on the growth of murine Colon 38 cancer cells in vitro.

Abstract


Introduction: Epidemiological studies underline the fact that obesity represents a significant risk factor for the development of several cancers, one of which is cancer of the colon. Moreover, multiple recent data indicate that some adipose tissue-derived hormones may influence the growth of malignant cells. Leptin, the product of the ob gene, is one of these. However, the evidence from research is still contradictory regarding the role of leptin in colon cancer. The aim of our study was to examine the direct effect of leptin at various concentrations (from 10-5 to 10-12 M) when applied alone or jointly with fluorouracil (the classical cytotoxic drug for colon cancer) at two concentrations (0.25 mg/ml and 2.5 mg/ml) on the growth of murine Colon 38 cancer cells in vitro.
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Keywords

leptin; fluorouracil; colon cancer

About this article
Title

Leptin promotes the growth of Colon 38 cancer cells and interferes with the cytotoxic effect of fluorouracil in vitro

Journal

Endokrynologia Polska

Issue

Vol 58, No 1 (2007)

Pages

2-6

Published online

2007-01-31

Bibliographic record

Endokrynologia Polska 2007;58(1):2-6.

Keywords

leptin
fluorouracil
colon cancer

Authors

Gabriela Mełeń-Mucha
Hanna Ławnicka

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