open access

Vol 58, No 2 (2007)
Original papers
Published online: 2007-03-13
Submitted: 2013-02-15
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Bone mineral density and bone turnover in hyperprolactinaemia of various origins

Beata Zadrożna-Śliwka, Marek Bolanowski, Marcin Kałużny, Joanna Syrycka
Endokrynologia Polska 2007;58(2):116-122.

open access

Vol 58, No 2 (2007)
Original papers
Published online: 2007-03-13
Submitted: 2013-02-15

Abstract

Introduction: Osteopoenia and osteoporosis because of hyperprolactinaemia caused by prolactinoma may be followed by an increased risk of fracture. There are no data on the bone effects of functional hyperprolactinaemia. The aim was to assess the influence of hyperprolactinaemia of various origins on bone turnover and density in different skeletal sites.
Material and methods: The study was carried out in 75 women (aged 30.53 ± 7.8): Group I - 32 women with prolactinoma and Group II - 43 women with functional hyperprolactinaemia. Both groups of patients were subdivided into those with hypogonadism and those with normal gonadal function. The control group consisted of 29 healthy women aged (33.59 ± 4.7). In all subjects PRL and bone turnover markers (BAP, OC, ICTP) were studied. BMD measurements (lumbar spine, forearm, proximal femur and total body) were carried out using DXA.
Results: Higher PRL concentrations were observed in patients than in controls. The values of bone turnover markers (BAP, ICTP) were shown to be higher in patient groups and subgroups than in controls. In patients with prolactinoma lumbar spine BMD was lower than in patients with functional hyperprolactinaemia and controls. Total body BMD was also lower, albeit to a lesser extent.
Conclusions: Hyperprolactinaemia caused by prolactinoma in women influences bone metabolism unfavourably, more by the impact on the activity of bone turnover markers than on BMD. This provides an opportunity for earlier assessment of bone metabolism disturbances before the BMD changes can be observed. Functional hyperprolactinaemia does not determine such a harmful effect on bone metabolism as hyperprolactinemia due to prolactinoma.

Abstract

Introduction: Osteopoenia and osteoporosis because of hyperprolactinaemia caused by prolactinoma may be followed by an increased risk of fracture. There are no data on the bone effects of functional hyperprolactinaemia. The aim was to assess the influence of hyperprolactinaemia of various origins on bone turnover and density in different skeletal sites.
Material and methods: The study was carried out in 75 women (aged 30.53 ± 7.8): Group I - 32 women with prolactinoma and Group II - 43 women with functional hyperprolactinaemia. Both groups of patients were subdivided into those with hypogonadism and those with normal gonadal function. The control group consisted of 29 healthy women aged (33.59 ± 4.7). In all subjects PRL and bone turnover markers (BAP, OC, ICTP) were studied. BMD measurements (lumbar spine, forearm, proximal femur and total body) were carried out using DXA.
Results: Higher PRL concentrations were observed in patients than in controls. The values of bone turnover markers (BAP, ICTP) were shown to be higher in patient groups and subgroups than in controls. In patients with prolactinoma lumbar spine BMD was lower than in patients with functional hyperprolactinaemia and controls. Total body BMD was also lower, albeit to a lesser extent.
Conclusions: Hyperprolactinaemia caused by prolactinoma in women influences bone metabolism unfavourably, more by the impact on the activity of bone turnover markers than on BMD. This provides an opportunity for earlier assessment of bone metabolism disturbances before the BMD changes can be observed. Functional hyperprolactinaemia does not determine such a harmful effect on bone metabolism as hyperprolactinemia due to prolactinoma.
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Keywords

prolactinoma; functional hyperprolactinaemia; bone mineral density; bone turnover

About this article
Title

Bone mineral density and bone turnover in hyperprolactinaemia of various origins

Journal

Endokrynologia Polska

Issue

Vol 58, No 2 (2007)

Pages

116-122

Published online

2007-03-13

Bibliographic record

Endokrynologia Polska 2007;58(2):116-122.

Keywords

prolactinoma
functional hyperprolactinaemia
bone mineral density
bone turnover

Authors

Beata Zadrożna-Śliwka
Marek Bolanowski
Marcin Kałużny
Joanna Syrycka

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