open access

Vol 58, No 3 (2007)
Postgraduate education
Published online: 2007-09-19
Submitted: 2013-02-15
Get Citation

LADA - Latent Autoimmune Diabetes in Adults

Małgorzata Szelachowska
Endokrynologia Polska 2007;58(3):246-251.

open access

Vol 58, No 3 (2007)
Postgraduate education
Published online: 2007-09-19
Submitted: 2013-02-15

Abstract

Latent Autoimmune Diabetes In Adults (LADA) is a form of autoimmune-mediated diabetes in adults. The progression of beta-cell failure is slower than in childhood type 1 diabetes. Patients with LADA present with more preserved beta-cell function than those with classic type 1 diabetes. The diagnosis of LADA according to Immunology of Diabetes Society is based on three features: age over 35 years, the presence at least one of four circulating autoantibodies to pancreatic islet cell antigens and lack of requirement for insulin at least 6 month after diagnosis. The level of C-peptide secretion after stimulation with intravenous glucagon helped to diagnosis. There are different opinions in relation to treatment of LADA.
Some studies suggest, that insulin treatment is indicated at the time of diagnosis LADA, some of them - when patients upon faillure of oral hypoglycemic treatment. (Pol J Endocrinol 2007; 58 (3): 246-251)

Abstract

Latent Autoimmune Diabetes In Adults (LADA) is a form of autoimmune-mediated diabetes in adults. The progression of beta-cell failure is slower than in childhood type 1 diabetes. Patients with LADA present with more preserved beta-cell function than those with classic type 1 diabetes. The diagnosis of LADA according to Immunology of Diabetes Society is based on three features: age over 35 years, the presence at least one of four circulating autoantibodies to pancreatic islet cell antigens and lack of requirement for insulin at least 6 month after diagnosis. The level of C-peptide secretion after stimulation with intravenous glucagon helped to diagnosis. There are different opinions in relation to treatment of LADA.
Some studies suggest, that insulin treatment is indicated at the time of diagnosis LADA, some of them - when patients upon faillure of oral hypoglycemic treatment. (Pol J Endocrinol 2007; 58 (3): 246-251)
Get Citation

Keywords

LADA; diabetes mellitus; diagnosis; treatment

About this article
Title

LADA - Latent Autoimmune Diabetes in Adults

Journal

Endokrynologia Polska

Issue

Vol 58, No 3 (2007)

Pages

246-251

Published online

2007-09-19

Bibliographic record

Endokrynologia Polska 2007;58(3):246-251.

Keywords

LADA
diabetes mellitus
diagnosis
treatment

Authors

Małgorzata Szelachowska

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