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Partial growth hormone deficiency (GHD) in children has more similarities to idiopathic short stature than to severe GHD
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Abstract
Material and methods: The analysis comprised 540 short children (373 boys, 167 girls), aged 11.7 ± 3.2 years. In all the patients two GH stimulation tests were performed, IGF-I serum concentration was measured, bone age was assessed and PAH was calculated. According to the GH peak in the two stimulation tests, the patients were classified into the following groups: severe GHD (sGHD) - GH peak < 5 ng/mL (n = 44), partial GHD (pGHD) - GH peak 5–10 ng/mL (n = 190), idiopathic short stature (ISS) - GH peak at least 10 ng/mL (n = 306).
Results: A significantly greater deficit of height, lower IGF-I secretion and worse PAH were observed in sGHD than in both remaining groups, while all the differences between pGHD and ISS in the parameters analysed were insignificant.
Conclusion: The results obtained indicate the necessity of applying another methods of qualifying short children for GH therapy other than GH stimulation tests with a cut-off value at a level of 10 ng/mL. (Pol J Endocrinol 2007; 58 (3): 182-187)
Abstract
Material and methods: The analysis comprised 540 short children (373 boys, 167 girls), aged 11.7 ± 3.2 years. In all the patients two GH stimulation tests were performed, IGF-I serum concentration was measured, bone age was assessed and PAH was calculated. According to the GH peak in the two stimulation tests, the patients were classified into the following groups: severe GHD (sGHD) - GH peak < 5 ng/mL (n = 44), partial GHD (pGHD) - GH peak 5–10 ng/mL (n = 190), idiopathic short stature (ISS) - GH peak at least 10 ng/mL (n = 306).
Results: A significantly greater deficit of height, lower IGF-I secretion and worse PAH were observed in sGHD than in both remaining groups, while all the differences between pGHD and ISS in the parameters analysed were insignificant.
Conclusion: The results obtained indicate the necessity of applying another methods of qualifying short children for GH therapy other than GH stimulation tests with a cut-off value at a level of 10 ng/mL. (Pol J Endocrinol 2007; 58 (3): 182-187)
Keywords
short stature; growth hormone deficiency; stimulation tests; insulin-like growth factor-I; predicted adult height
About this articleTitle
Partial growth hormone deficiency (GHD) in children has more similarities to idiopathic short stature than to severe GHD
Journal
Issue
Article type
Original paper
Pages
182-187
Published online
2007-09-19
Page views
526
Article views/downloads
922
DOI
10.5603/ep.25626
Bibliographic record
Endokrynol Pol 2007;58(3):182-187.
Keywords
short stature
growth hormone deficiency
stimulation tests
insulin-like growth factor-I
predicted adult height
Authors
Joanna Smyczyńska
Andrzej Lewiński
Maciej Hilczer
Renata Stawerska
Michał Karasek
