open access

Vol 58, No 4 (2007)
Postgraduate education
Published online: 2007-05-17
Submitted: 2013-02-15
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Natriuretic peptides: their role in diagnosis and therapy

Dorota Pakuła, Bogdan Marek, Dariusz Kajdaniuk, Beata Kos-Kudła, Halina Borgiel-Marek, Robert Krysiak, Aleksander Gatnar, Piotr Pakuła
Endokrynologia Polska 2007;58(4):364-375.

open access

Vol 58, No 4 (2007)
Postgraduate education
Published online: 2007-05-17
Submitted: 2013-02-15

Abstract

Cardiac natriuretic peptide hormones, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are synthesized and secreted by the heart, producing several biological effects, such as natriuresis, vasorelaxation and hypotension. During the last decade these peptides, especially BNP, have received increasing attention as potential markers of cardiovascular disease. Their measurements can be used to diagnose heart failure, including diastolic dysfunction, and using them has been shown to save money. BNP levels can enable the differentation between dyspnoic patients secondary to ventricular dysfunction and subjects with primary respiratory disorders. Moreover, there is good evidence that natriuretic peptides may have a diagnostic role in arterial hypertension, acute coronary syndromes, pulmonary hypertension, some valvular heart disease and some disorders affecting other systems (diabetes or thyroid disorders). In this paper we disscuss the clinical utility of assessment of natriuretic peptide hormones in the diagnosis of various clinical conditions and their use as pharmacological agents.
(Pol J Endocrinol 2007; 58 (4): 364-374)

Abstract

Cardiac natriuretic peptide hormones, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are synthesized and secreted by the heart, producing several biological effects, such as natriuresis, vasorelaxation and hypotension. During the last decade these peptides, especially BNP, have received increasing attention as potential markers of cardiovascular disease. Their measurements can be used to diagnose heart failure, including diastolic dysfunction, and using them has been shown to save money. BNP levels can enable the differentation between dyspnoic patients secondary to ventricular dysfunction and subjects with primary respiratory disorders. Moreover, there is good evidence that natriuretic peptides may have a diagnostic role in arterial hypertension, acute coronary syndromes, pulmonary hypertension, some valvular heart disease and some disorders affecting other systems (diabetes or thyroid disorders). In this paper we disscuss the clinical utility of assessment of natriuretic peptide hormones in the diagnosis of various clinical conditions and their use as pharmacological agents.
(Pol J Endocrinol 2007; 58 (4): 364-374)
Get Citation

Keywords

cardiac natriuretic peptides; heart failure; thyroid disorders

About this article
Title

Natriuretic peptides: their role in diagnosis and therapy

Journal

Endokrynologia Polska

Issue

Vol 58, No 4 (2007)

Pages

364-375

Published online

2007-05-17

Bibliographic record

Endokrynologia Polska 2007;58(4):364-375.

Keywords

cardiac natriuretic peptides
heart failure
thyroid disorders

Authors

Dorota Pakuła
Bogdan Marek
Dariusz Kajdaniuk
Beata Kos-Kudła
Halina Borgiel-Marek
Robert Krysiak
Aleksander Gatnar
Piotr Pakuła

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