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Corticosteroids influence on angiogenesis in heart muscle
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Abstract
The goal of therapeutic angiogenesis is to stimulate the growth of new capillaries in a heart and, as a result, to improve the perfusion and function of a heart muscle.
The positive impact of the angiogenesis in a heart muscle is impeded in patients using corticosteroids in treatment for other illnesses. Corticosteroids inhibit the angiogenesis process on a cellular and tissue level. They decrease gene expression for VEGF, iNOS, inhibit the activity of transcriptive factors for AP-1 and NFkB. Corticosteroids cause the degradation of a pericellular matrix, inhibit the migration of macrophages and inhibit the synthesis of NO and interleukin. These activities of corticosteroids decrease the number of new vessels in a ischaemic miocardium and, consequently, worsen vascularization and progressive hypoxia.
(Pol J Endocrinol 2007; 58 (5): 436-439)
Abstract
The goal of therapeutic angiogenesis is to stimulate the growth of new capillaries in a heart and, as a result, to improve the perfusion and function of a heart muscle.
The positive impact of the angiogenesis in a heart muscle is impeded in patients using corticosteroids in treatment for other illnesses. Corticosteroids inhibit the angiogenesis process on a cellular and tissue level. They decrease gene expression for VEGF, iNOS, inhibit the activity of transcriptive factors for AP-1 and NFkB. Corticosteroids cause the degradation of a pericellular matrix, inhibit the migration of macrophages and inhibit the synthesis of NO and interleukin. These activities of corticosteroids decrease the number of new vessels in a ischaemic miocardium and, consequently, worsen vascularization and progressive hypoxia.
(Pol J Endocrinol 2007; 58 (5): 436-439)
Keywords
corticosteroids; angiogenesis; heart muscle
Title
Corticosteroids influence on angiogenesis in heart muscle
Journal
Issue
Article type
Review paper
Pages
436-439
Published online
2007-10-16
Page views
2143
Article views/downloads
1104
Bibliographic record
Endokrynol Pol 2007;58(5):436-439.
Keywords
corticosteroids
angiogenesis
heart muscle
Authors
Jadwiga Jośko
Katarzyna Ratman
Rajmund M. Ratman