Vol 58, No 6 (2007)
Review paper
Published online: 2007-11-21
Sodium iodide symporter in physiology and diseases - the current state of knowledge
Endokrynol Pol 2007;58(6):512-521.
Abstract
The sodium iodide symporter, called also the NIS protein is responsible for iodine trapping to the cell what is significant for
the thyroid function. Identified and described for the first time in 1996 NIS protein is the matter of interest of investigators
concerning the thyroid physiology and pathology as well as others organs which concentrate the iodine. Existing studies
on the sodium iodide symporter include among others: indicating NIS protein expression in the thyroid diseases and
extrathyroidal tissues, studying of the NIS antygenicity in the autoimmune diseases of thyroid, finding the molecular
aspects of the difference in the NIS protein activity. The sodium iodide symporter is a base of radioiodine therapy of, as for
now, thyroid diseases only. Showing NIS protein expression in other cancerous tissues provide a new therapeutic strategy
for a variety of human cancers. Additionally, latest explorations indicate at an innovative destination of the studies concerning
the sodium iodide symporter that is the gene therapy with the use of gene NIS transfer.
Keywords: sodium iodide symporterNIS proteinthyroidautoimmune diseasesnodular goiterthyroid cancergene therapy
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