open access

Vol 58, No 6 (2007)
Original papers
Published online: 2007-11-21
Submitted: 2013-02-15
Get Citation

Assessment of selected haemostatic parameters in obese patients

Renata Świątkowska-Stodulska, Anna Skibowska-Bielińska, Alicja Bąkowska, Piotr Wiśniewski, Krzysztof Sworczak
Endokrynologia Polska 2007;58(6):505-509.

open access

Vol 58, No 6 (2007)
Original papers
Published online: 2007-11-21
Submitted: 2013-02-15

Abstract

Background: Epidemiologic data show significantly higher frequency of thromboembolic incidents in obesity than in normal weight persons. Disorders of haemostasis seem to play a crucial role in their development. In the literature there are only few papers assessing coagulation and fibrynolitic parameters in obese subjects.
Aim of the study: Assessment of protein C (PC), antithrombin (AT) and α2 antiplasmin (α2AP) activity and thrombomodulin (TM) concentration in the blood plasma of obese person (BMI > 30 kg/m2).
Materials and methods: The study involved 32 patients (22 women and 10 men, mean age 39.7 ± 15.3 years) and 20 healthy volunteers matched correctly according to sex and age who constituted a control group. In the examined subjects activity of PC, AT, α2 AP were assessed by means of the colorimetric methods and TM concentration in the blood plasma using ELISA method.
Results: No statistically significant differences in activities of PC, AT, α2 AP and TM concentrations between the patients and the control group were found. However the tendency to higher activities of PC and concentrations of TM were noticed in the obese patients. Assessing tested parameters according to sex, statistically significant differences were found in AT activity between the male patients and healthy men. Statistically lower values, but still in the normal range, were found in the obese men. Comparing the groups of women, significantly lower concentrations of TM were found in the obese ones.
Conclusions: It seems that changed values of PC, AT, α2 AP activities are not responsible for increased risk of thromboembolic events in obese persons. Increased TM concentration in obese, may indirectly indicate endothelium damage.

Abstract

Background: Epidemiologic data show significantly higher frequency of thromboembolic incidents in obesity than in normal weight persons. Disorders of haemostasis seem to play a crucial role in their development. In the literature there are only few papers assessing coagulation and fibrynolitic parameters in obese subjects.
Aim of the study: Assessment of protein C (PC), antithrombin (AT) and α2 antiplasmin (α2AP) activity and thrombomodulin (TM) concentration in the blood plasma of obese person (BMI > 30 kg/m2).
Materials and methods: The study involved 32 patients (22 women and 10 men, mean age 39.7 ± 15.3 years) and 20 healthy volunteers matched correctly according to sex and age who constituted a control group. In the examined subjects activity of PC, AT, α2 AP were assessed by means of the colorimetric methods and TM concentration in the blood plasma using ELISA method.
Results: No statistically significant differences in activities of PC, AT, α2 AP and TM concentrations between the patients and the control group were found. However the tendency to higher activities of PC and concentrations of TM were noticed in the obese patients. Assessing tested parameters according to sex, statistically significant differences were found in AT activity between the male patients and healthy men. Statistically lower values, but still in the normal range, were found in the obese men. Comparing the groups of women, significantly lower concentrations of TM were found in the obese ones.
Conclusions: It seems that changed values of PC, AT, α2 AP activities are not responsible for increased risk of thromboembolic events in obese persons. Increased TM concentration in obese, may indirectly indicate endothelium damage.
Get Citation

Keywords

disturbances of haemostasis; fibrynolysis; obesity

About this article
Title

Assessment of selected haemostatic parameters in obese patients

Journal

Endokrynologia Polska

Issue

Vol 58, No 6 (2007)

Pages

505-509

Published online

2007-11-21

Bibliographic record

Endokrynologia Polska 2007;58(6):505-509.

Keywords

disturbances of haemostasis
fibrynolysis
obesity

Authors

Renata Świątkowska-Stodulska
Anna Skibowska-Bielińska
Alicja Bąkowska
Piotr Wiśniewski
Krzysztof Sworczak

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl