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Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases
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Abstract
Material and methods: 3 groups of subjects: 1/25 patients with GD in euthyreosis on methimazol 2/27 patients with ChH in euthyreosis on levothyroxine. 3/12 healthy volunteers age and sex-matched to group 1-2. The serum levels of Fas, FasL and Bcl-2 were determined by the ELISA kit.
Results: We found positive correlations between sFas and age in GD patients (r = 0.35; p < 0.05). In GD patients we found a negative correlation between sFasL and age in all studied patients with AITD (r = –0.34; p < 0.01). We also found a negative correlation between sBcl-2 and age in HT patients (r = –0.42; p < 0.05).
Conclusions: Fas/FasL and Bcl-2 signaling pathways seem to be age-related and may explain, at least in part, milder course of Graves´ disease in elderly patients and increased prevalence of Hashimoto disease in this group of subjects.
Abstract
Material and methods: 3 groups of subjects: 1/25 patients with GD in euthyreosis on methimazol 2/27 patients with ChH in euthyreosis on levothyroxine. 3/12 healthy volunteers age and sex-matched to group 1-2. The serum levels of Fas, FasL and Bcl-2 were determined by the ELISA kit.
Results: We found positive correlations between sFas and age in GD patients (r = 0.35; p < 0.05). In GD patients we found a negative correlation between sFasL and age in all studied patients with AITD (r = –0.34; p < 0.01). We also found a negative correlation between sBcl-2 and age in HT patients (r = –0.42; p < 0.05).
Conclusions: Fas/FasL and Bcl-2 signaling pathways seem to be age-related and may explain, at least in part, milder course of Graves´ disease in elderly patients and increased prevalence of Hashimoto disease in this group of subjects.
Keywords
sFas; sFasL; sBcl-2; Graves’ disease; Hashimoto’s thyroiditis; age
About this articleTitle
Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases
Journal
Issue
Article type
Original paper
Pages
492-495
Published online
2007-11-21
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530
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1524
Bibliographic record
Endokrynol Pol 2007;58(6):492-495.
Keywords
sFas
sFasL
sBcl-2
Graves’ disease
Hashimoto’s thyroiditis
age
Authors
Janusz Myśliwiec
Magdalena Okłota
Agnieszka Nikołajuk
Maria Górska
