open access

Vol 58, No 6 (2007)
Original papers
Published online: 2007-11-21
Submitted: 2013-02-15
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Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases

Janusz Myśliwiec, Magdalena Okłota, Agnieszka Nikołajuk, Maria Górska
Endokrynologia Polska 2007;58(6):492-495.

open access

Vol 58, No 6 (2007)
Original papers
Published online: 2007-11-21
Submitted: 2013-02-15

Abstract

Introduction: Apoptosis plays a pivotal role in the regulation of immune mechanisms in the pathogenesis of autoimmune thyroid diseases (AITD). The prevalence of AITD increases with age. Purpose to compare soluble Fas, FasL and Bcl-2 in Graves´ disease (GD) and Hashimoto thyroiditis (HT) in relation to the age of the studied patients.
Material and methods: 3 groups of subjects: 1/25 patients with GD in euthyreosis on methimazol 2/27 patients with ChH in euthyreosis on levothyroxine. 3/12 healthy volunteers age and sex-matched to group 1-2. The serum levels of Fas, FasL and Bcl-2 were determined by the ELISA kit.
Results: We found positive correlations between sFas and age in GD patients (r = 0.35; p < 0.05). In GD patients we found a negative correlation between sFasL and age in all studied patients with AITD (r = &#8211;0.34; p < 0.01). We also found a negative correlation between sBcl-2 and age in HT patients (r = &#8211;0.42; p < 0.05).
Conclusions: Fas/FasL and Bcl-2 signaling pathways seem to be age-related and may explain, at least in part, milder course of Graves´ disease in elderly patients and increased prevalence of Hashimoto disease in this group of subjects.

Abstract

Introduction: Apoptosis plays a pivotal role in the regulation of immune mechanisms in the pathogenesis of autoimmune thyroid diseases (AITD). The prevalence of AITD increases with age. Purpose to compare soluble Fas, FasL and Bcl-2 in Graves´ disease (GD) and Hashimoto thyroiditis (HT) in relation to the age of the studied patients.
Material and methods: 3 groups of subjects: 1/25 patients with GD in euthyreosis on methimazol 2/27 patients with ChH in euthyreosis on levothyroxine. 3/12 healthy volunteers age and sex-matched to group 1-2. The serum levels of Fas, FasL and Bcl-2 were determined by the ELISA kit.
Results: We found positive correlations between sFas and age in GD patients (r = 0.35; p < 0.05). In GD patients we found a negative correlation between sFasL and age in all studied patients with AITD (r = &#8211;0.34; p < 0.01). We also found a negative correlation between sBcl-2 and age in HT patients (r = &#8211;0.42; p < 0.05).
Conclusions: Fas/FasL and Bcl-2 signaling pathways seem to be age-related and may explain, at least in part, milder course of Graves´ disease in elderly patients and increased prevalence of Hashimoto disease in this group of subjects.
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Keywords

sFas; sFasL; sBcl-2; Graves’ disease; Hashimoto’s thyroiditis; age

About this article
Title

Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases

Journal

Endokrynologia Polska

Issue

Vol 58, No 6 (2007)

Pages

492-495

Published online

2007-11-21

Bibliographic record

Endokrynologia Polska 2007;58(6):492-495.

Keywords

sFas
sFasL
sBcl-2
Graves’ disease
Hashimoto’s thyroiditis
age

Authors

Janusz Myśliwiec
Magdalena Okłota
Agnieszka Nikołajuk
Maria Górska

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