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The blood concentration of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in patients with active thyroid-associated orbitopathy before and after methylprednisolone treatment
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Abstract
Material and methods: The study was performed in 40 Graves´disease, hyperthyroid and euthyroid patients with a clinically active form of TAO. Serum concentrations of sVCAM-1 and sICAM-1 in TAO patients were determined by enzymelinked immunoabsorbent assay (ELISA) before and after intensive pulse methylprednisolone treatment.
Results: We did not find any significant changes in the studied parameters between TAO patients with hyperthyroidism and those with euthyroidism. The serum concentrations of sICAM-1 and sVCAM-1 were significantly increased in patients with TAO before methylprednisolone therapy when compared with the control group. After treatment serum concentrations of sICAM-1 and sVCAM-1 decreased significantly but were still significantly higher than for the control group.
Conclusion: From the results obtained we can conclude that Graves´ orbitopathy itself but not thyroid function is probably responsible for the elevated level of the adhesion molecules studied.
Abstract
Material and methods: The study was performed in 40 Graves´disease, hyperthyroid and euthyroid patients with a clinically active form of TAO. Serum concentrations of sVCAM-1 and sICAM-1 in TAO patients were determined by enzymelinked immunoabsorbent assay (ELISA) before and after intensive pulse methylprednisolone treatment.
Results: We did not find any significant changes in the studied parameters between TAO patients with hyperthyroidism and those with euthyroidism. The serum concentrations of sICAM-1 and sVCAM-1 were significantly increased in patients with TAO before methylprednisolone therapy when compared with the control group. After treatment serum concentrations of sICAM-1 and sVCAM-1 decreased significantly but were still significantly higher than for the control group.
Conclusion: From the results obtained we can conclude that Graves´ orbitopathy itself but not thyroid function is probably responsible for the elevated level of the adhesion molecules studied.
Keywords
adhesion molecules; thyroid-associated orbitopathy
About this articleTitle
The blood concentration of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in patients with active thyroid-associated orbitopathy before and after methylprednisolone treatment
Journal
Issue
Article type
Original paper
Pages
487-491
Published online
2007-11-21
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550
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960
Bibliographic record
Endokrynol Pol 2007;58(6):487-491.
Keywords
adhesion molecules
thyroid-associated orbitopathy
Authors
Mariusz Nowak
Tomasz Wielkoszyński
Beata Kos-Kudła
Bogdan Marek
Jacek Karpe
Dariusz Kajdaniuk
Lucyna Siemińska
Joanna Głogowska-Szeląg
Wanda Foltyn
Janusz Strzelczyk
Katarzyna Nowak
