open access

Vol 58, No 6 (2007)
Original papers
Published online: 2007-11-21
Submitted: 2013-02-15
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The blood concentration of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in patients with active thyroid-associated orbitopathy before and after methylprednisolone treatment

Mariusz Nowak, Tomasz Wielkoszyński, Beata Kos-Kudła, Bogdan Marek, Jacek Karpe, Dariusz Kajdaniuk, Lucyna Siemińska, Joanna Głogowska-Szeląg, Wanda Foltyn, Janusz Strzelczyk, Katarzyna Nowak
Endokrynologia Polska 2007;58(6):487-491.

open access

Vol 58, No 6 (2007)
Original papers
Published online: 2007-11-21
Submitted: 2013-02-15

Abstract

Background: The soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) have been found to be increased in the blood of patients with Graves´ disease. The aim of this study is evaluation of the serum concentrations of soluble forms of adhesion molecules ICAM-1 and VCAM-1 in patients with thyroid-associated orbitopathy (TAO) before and after methylprednisolone treatment.
Material and methods: The study was performed in 40 Graves´disease, hyperthyroid and euthyroid patients with a clinically active form of TAO. Serum concentrations of sVCAM-1 and sICAM-1 in TAO patients were determined by enzymelinked immunoabsorbent assay (ELISA) before and after intensive pulse methylprednisolone treatment.
Results: We did not find any significant changes in the studied parameters between TAO patients with hyperthyroidism and those with euthyroidism. The serum concentrations of sICAM-1 and sVCAM-1 were significantly increased in patients with TAO before methylprednisolone therapy when compared with the control group. After treatment serum concentrations of sICAM-1 and sVCAM-1 decreased significantly but were still significantly higher than for the control group.
Conclusion: From the results obtained we can conclude that Graves´ orbitopathy itself but not thyroid function is probably responsible for the elevated level of the adhesion molecules studied.

Abstract

Background: The soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) have been found to be increased in the blood of patients with Graves´ disease. The aim of this study is evaluation of the serum concentrations of soluble forms of adhesion molecules ICAM-1 and VCAM-1 in patients with thyroid-associated orbitopathy (TAO) before and after methylprednisolone treatment.
Material and methods: The study was performed in 40 Graves´disease, hyperthyroid and euthyroid patients with a clinically active form of TAO. Serum concentrations of sVCAM-1 and sICAM-1 in TAO patients were determined by enzymelinked immunoabsorbent assay (ELISA) before and after intensive pulse methylprednisolone treatment.
Results: We did not find any significant changes in the studied parameters between TAO patients with hyperthyroidism and those with euthyroidism. The serum concentrations of sICAM-1 and sVCAM-1 were significantly increased in patients with TAO before methylprednisolone therapy when compared with the control group. After treatment serum concentrations of sICAM-1 and sVCAM-1 decreased significantly but were still significantly higher than for the control group.
Conclusion: From the results obtained we can conclude that Graves´ orbitopathy itself but not thyroid function is probably responsible for the elevated level of the adhesion molecules studied.
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Keywords

adhesion molecules; thyroid-associated orbitopathy

About this article
Title

The blood concentration of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in patients with active thyroid-associated orbitopathy before and after methylprednisolone treatment

Journal

Endokrynologia Polska

Issue

Vol 58, No 6 (2007)

Pages

487-491

Published online

2007-11-21

Bibliographic record

Endokrynologia Polska 2007;58(6):487-491.

Keywords

adhesion molecules
thyroid-associated orbitopathy

Authors

Mariusz Nowak
Tomasz Wielkoszyński
Beata Kos-Kudła
Bogdan Marek
Jacek Karpe
Dariusz Kajdaniuk
Lucyna Siemińska
Joanna Głogowska-Szeląg
Wanda Foltyn
Janusz Strzelczyk
Katarzyna Nowak

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