open access

Vol 59, No 1 (2008)
Original papers
Published online: 2008-01-21
Submitted: 2013-02-15
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The effect of weight loss on inflammation in obese women with polycystic ovary syndrome

Magdalena Olszanecka-Glinianowicz, Barbara Zahorska-Markiewicz, Piotr Kocełak, Joanna Janowska, Elżbieta Semik-Grabarczyk
Endokrynologia Polska 2008;59(1):13-17.

open access

Vol 59, No 1 (2008)
Original papers
Published online: 2008-01-21
Submitted: 2013-02-15

Abstract

Introduction: The aim of the present study was to evaluate the effect of modest weight reduction on serum concentrations of tumour necrosis factor α (TNF-α), TNF soluble receptors (sTNFRs) and interleukin-6 (IL-6) in obese women with polycystic ovary syndrome (PCOS).
Material and methods: The study group consisted of 15 obese women with PCOS (mean age 28.5 ± 7.7 years). Serum concentrations of TNF-α, sTNFRs and IL-6, insulin, FSH, LH, DHEAS, androstendione, total and free testosterone, cortisol, 17OH-progesterone, oestradiol and sex hormone binding globulin (SHBG), glucose, total cholesterol, HDL cholesterol and triglycerides were measured before treatment and after 10% weight loss. All patients were advised to follow a 1000-1200 kcal diet with a limited intake of simple carbohydrate and animal fats and to exercise regularly (30 min, 3 times a week). Body composition was measured by bioimpedance. Serum concentrations of TNF-α, sTNFRs and IL-6 were determined by enzyme linked immunosorbent assay (ELISA). Plasma insulin, FSH, LH, DHEAS, androstendione, total and free testosterone, cortisol, 17OH-progesterone, oestradiol and SHBG were measured by a commercial RIA. Blood glucose, total cholesterol, HDL cholesterol and triglycerides were measured by an enzymatic procedure.
Results: We observed no differences in serum concentrations of TNF-α, sTNFRs or IL-6 after treatment.
Conclusions: It seems that more than a modest weight reduction is necessary to obtain a decrease in serum concentrations of proinflammatory cytokines and an improvement in ovarian function in obese women with polycystic ovary syndrome.
Pol J Endocrinol 2008; 59 (1): 13-17

Abstract

Introduction: The aim of the present study was to evaluate the effect of modest weight reduction on serum concentrations of tumour necrosis factor α (TNF-α), TNF soluble receptors (sTNFRs) and interleukin-6 (IL-6) in obese women with polycystic ovary syndrome (PCOS).
Material and methods: The study group consisted of 15 obese women with PCOS (mean age 28.5 ± 7.7 years). Serum concentrations of TNF-α, sTNFRs and IL-6, insulin, FSH, LH, DHEAS, androstendione, total and free testosterone, cortisol, 17OH-progesterone, oestradiol and sex hormone binding globulin (SHBG), glucose, total cholesterol, HDL cholesterol and triglycerides were measured before treatment and after 10% weight loss. All patients were advised to follow a 1000-1200 kcal diet with a limited intake of simple carbohydrate and animal fats and to exercise regularly (30 min, 3 times a week). Body composition was measured by bioimpedance. Serum concentrations of TNF-α, sTNFRs and IL-6 were determined by enzyme linked immunosorbent assay (ELISA). Plasma insulin, FSH, LH, DHEAS, androstendione, total and free testosterone, cortisol, 17OH-progesterone, oestradiol and SHBG were measured by a commercial RIA. Blood glucose, total cholesterol, HDL cholesterol and triglycerides were measured by an enzymatic procedure.
Results: We observed no differences in serum concentrations of TNF-α, sTNFRs or IL-6 after treatment.
Conclusions: It seems that more than a modest weight reduction is necessary to obtain a decrease in serum concentrations of proinflammatory cytokines and an improvement in ovarian function in obese women with polycystic ovary syndrome.
Pol J Endocrinol 2008; 59 (1): 13-17
Get Citation

Keywords

proinflammatory cytokines; weight reduction; polycystic ovary syndrome

About this article
Title

The effect of weight loss on inflammation in obese women with polycystic ovary syndrome

Journal

Endokrynologia Polska

Issue

Vol 59, No 1 (2008)

Pages

13-17

Published online

2008-01-21

Bibliographic record

Endokrynologia Polska 2008;59(1):13-17.

Keywords

proinflammatory cytokines
weight reduction
polycystic ovary syndrome

Authors

Magdalena Olszanecka-Glinianowicz
Barbara Zahorska-Markiewicz
Piotr Kocełak
Joanna Janowska
Elżbieta Semik-Grabarczyk

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