open access

Vol 59, No 1 (2008)
Original papers
Published online: 2008-01-21
Submitted: 2013-02-15
Get Citation

A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy

Mariusz Nowak, Tomasz Wielkoszyński, Bogdan Marek, Beata Kos-Kudła, Elżbieta Świętochowska, Lucyna Siemińska, Dariusz Kajdaniuk, Joanna Głogowska-Szeląg, Katarzyna Nowak
Endokrynologia Polska 2008;59(1):2-5.

open access

Vol 59, No 1 (2008)
Original papers
Published online: 2008-01-21
Submitted: 2013-02-15

Abstract

,b>Introduction: The aim of this study was to evaluate the blood concentration of hepatocyte growth factor (HGF) in patients at various stages of retinopathy. We hypothesised that the high level of HGF found in diabetic patients may be an important marker of retinopathy progression and that HGF level may be an index of the risk of proliferative retinopathy.
Material and methods: The participants in the study were 76 patients with type 1 diabetes mellitus. Of these, 35 patients were without retinopathy and formed Group 1. Of the remaining 41 patients with retinopathy, 20 patients had non-proliferative diabetic retinopathy (NPDR) and formed Group 2, while 21 patients had proliferative diabetic retinopathy (PDR) and formed Group 3. We evaluated the concentration of HGF In the peripheral blood by an enzyme-linked immunosorbent assay.
Results: Mean serum concentrations of HGF in the control group were significantly lower than in the type 1 diabetic patients. We found a significant increase in HGF serum concentrations in diabetic patients with PDR compared with the control group. Mean serum HGF concentrations were significantly higher in diabetic subjects with PDR than in diabetic patients without retinopathy.
Conclusion: HGF concentration is increased in patients with type 1 diabetes mellitus with proliferative retinopathy, and concentrations increase with the progression of retinopathy, suggesting that HGF plays a role in the pathogenesis of proliferative diabetic retinopathy.
Pol J Endocrinol 2008; 59 (1): 2-5

Abstract

,b>Introduction: The aim of this study was to evaluate the blood concentration of hepatocyte growth factor (HGF) in patients at various stages of retinopathy. We hypothesised that the high level of HGF found in diabetic patients may be an important marker of retinopathy progression and that HGF level may be an index of the risk of proliferative retinopathy.
Material and methods: The participants in the study were 76 patients with type 1 diabetes mellitus. Of these, 35 patients were without retinopathy and formed Group 1. Of the remaining 41 patients with retinopathy, 20 patients had non-proliferative diabetic retinopathy (NPDR) and formed Group 2, while 21 patients had proliferative diabetic retinopathy (PDR) and formed Group 3. We evaluated the concentration of HGF In the peripheral blood by an enzyme-linked immunosorbent assay.
Results: Mean serum concentrations of HGF in the control group were significantly lower than in the type 1 diabetic patients. We found a significant increase in HGF serum concentrations in diabetic patients with PDR compared with the control group. Mean serum HGF concentrations were significantly higher in diabetic subjects with PDR than in diabetic patients without retinopathy.
Conclusion: HGF concentration is increased in patients with type 1 diabetes mellitus with proliferative retinopathy, and concentrations increase with the progression of retinopathy, suggesting that HGF plays a role in the pathogenesis of proliferative diabetic retinopathy.
Pol J Endocrinol 2008; 59 (1): 2-5
Get Citation

Keywords

hepatocyte growth factor; type 1 diabetes mellitus; diabetic retinopathy

About this article
Title

A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy

Journal

Endokrynologia Polska

Issue

Vol 59, No 1 (2008)

Pages

2-5

Published online

2008-01-21

Bibliographic record

Endokrynologia Polska 2008;59(1):2-5.

Keywords

hepatocyte growth factor
type 1 diabetes mellitus
diabetic retinopathy

Authors

Mariusz Nowak
Tomasz Wielkoszyński
Bogdan Marek
Beata Kos-Kudła
Elżbieta Świętochowska
Lucyna Siemińska
Dariusz Kajdaniuk
Joanna Głogowska-Szeląg
Katarzyna Nowak

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl