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A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy
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Abstract
Material and methods: The participants in the study were 76 patients with type 1 diabetes mellitus. Of these, 35 patients were without retinopathy and formed Group 1. Of the remaining 41 patients with retinopathy, 20 patients had non-proliferative diabetic retinopathy (NPDR) and formed Group 2, while 21 patients had proliferative diabetic retinopathy (PDR) and formed Group 3. We evaluated the concentration of HGF In the peripheral blood by an enzyme-linked immunosorbent assay.
Results: Mean serum concentrations of HGF in the control group were significantly lower than in the type 1 diabetic patients. We found a significant increase in HGF serum concentrations in diabetic patients with PDR compared with the control group. Mean serum HGF concentrations were significantly higher in diabetic subjects with PDR than in diabetic patients without retinopathy.
Conclusion: HGF concentration is increased in patients with type 1 diabetes mellitus with proliferative retinopathy, and concentrations increase with the progression of retinopathy, suggesting that HGF plays a role in the pathogenesis of proliferative diabetic retinopathy.
Pol J Endocrinol 2008; 59 (1): 2-5
Abstract
Material and methods: The participants in the study were 76 patients with type 1 diabetes mellitus. Of these, 35 patients were without retinopathy and formed Group 1. Of the remaining 41 patients with retinopathy, 20 patients had non-proliferative diabetic retinopathy (NPDR) and formed Group 2, while 21 patients had proliferative diabetic retinopathy (PDR) and formed Group 3. We evaluated the concentration of HGF In the peripheral blood by an enzyme-linked immunosorbent assay.
Results: Mean serum concentrations of HGF in the control group were significantly lower than in the type 1 diabetic patients. We found a significant increase in HGF serum concentrations in diabetic patients with PDR compared with the control group. Mean serum HGF concentrations were significantly higher in diabetic subjects with PDR than in diabetic patients without retinopathy.
Conclusion: HGF concentration is increased in patients with type 1 diabetes mellitus with proliferative retinopathy, and concentrations increase with the progression of retinopathy, suggesting that HGF plays a role in the pathogenesis of proliferative diabetic retinopathy.
Pol J Endocrinol 2008; 59 (1): 2-5
Keywords
hepatocyte growth factor; type 1 diabetes mellitus; diabetic retinopathy
About this articleTitle
A comparison of the levels of hepatocyte growth factor in serum in patients with type 1 diabetes mellitus with different stages of diabetic retinopathy
Journal
Issue
Article type
Original paper
Pages
2-5
Published online
2008-01-21
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754
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1134
Bibliographic record
Endokrynol Pol 2008;59(1):2-5.
Keywords
hepatocyte growth factor
type 1 diabetes mellitus
diabetic retinopathy
Authors
Mariusz Nowak
Tomasz Wielkoszyński
Bogdan Marek
Beata Kos-Kudła
Elżbieta Świętochowska
Lucyna Siemińska
Dariusz Kajdaniuk
Joanna Głogowska-Szeląg
Katarzyna Nowak
