Vol 59, No 2 (2008)
Review paper
Published online: 2008-05-08
The role of peroxisome proliferators-activated receptors (PPARγ) in neoplasms of endocrine glands
Endokrynol Pol 2008;59(2):156-167.
Abstract
The peroxisome proliferators-activated receptors gamma (PPAR) belong to the family of nuclear receptors, which directly regulate transcription
of target genes. PPARγ take part in many processes such as adipogenesis, glucose and lipid metabolism, atherosclerosis and
inflammation and carcinogenesis. The expression of PPARγ was detected in normal and tumor cells of endocrine glands. Activation of
receptors by specific ligands of PPARγ induces inhibition of cell proliferation, induction of apoptosis and terminal differentiation as well as
inhibition of angiogenesis. In the present paper the structure, tissue expression and biological function of PPARγ are presented. The
reports about oncostatic effects of PPARγ agonists in pituitary adenomas, thyroid cancers and adrenal tumor are reviewed.
(Pol J Endocrinol 2008; 59 (2): 156-166)
Keywords: PPARγpituitary adenomasthyroid cancersadrenal tumorsoncostatic effectPPARγ agonists
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