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The early treatment results of well differentiated thyroid cancer and its dependence on chosen factors
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Abstract
Introduction: The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.
Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.
Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25.3% (23/91) follicular thyroid cancers, and 6.6% (6/91) oxyphilic thyroid cancers. Among the group, 74 (81.3%) patients reached the remission criteria and the remaining 17 patients (18.7%) showed biochemical and morphological evidence of metastatic disease. The remission was obtained in 100% of patients in stage I of the disease, 68.4% - in stage II, 78.6% - in stage III and 33.3% in stage IV. The total radioiodine dose used in patients with remission, did not differ from the dose used in patients without remission. We did not observe the influence of remnant’s volume on treatment efficacy, however larger remants required higher dose of radioiodine to obtain the remission. Patients with remission had lower postsurgical thyroglobulin concentration than patients without remission. (22.2 vs. 103.3 ng/ml; p = 0.00025).
Conclusions: Early treatment results of well differentiated thyroid cancer depend on the clinical stage, and postoperative serum thyroglobulin level measured after endogenous TSH stimulation. Early treatment results are not dependent on age, sex, histological type of thyroid cancer, the dose of radioiodine used in brackets of 60-150 mCi and additional diseases. Total thyroidectomy is equally efficient as near total. (Pol J Endocrinol 2008; 59 (1): 123-130)
Abstract
Introduction: The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.
Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.
Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25.3% (23/91) follicular thyroid cancers, and 6.6% (6/91) oxyphilic thyroid cancers. Among the group, 74 (81.3%) patients reached the remission criteria and the remaining 17 patients (18.7%) showed biochemical and morphological evidence of metastatic disease. The remission was obtained in 100% of patients in stage I of the disease, 68.4% - in stage II, 78.6% - in stage III and 33.3% in stage IV. The total radioiodine dose used in patients with remission, did not differ from the dose used in patients without remission. We did not observe the influence of remnant’s volume on treatment efficacy, however larger remants required higher dose of radioiodine to obtain the remission. Patients with remission had lower postsurgical thyroglobulin concentration than patients without remission. (22.2 vs. 103.3 ng/ml; p = 0.00025).
Conclusions: Early treatment results of well differentiated thyroid cancer depend on the clinical stage, and postoperative serum thyroglobulin level measured after endogenous TSH stimulation. Early treatment results are not dependent on age, sex, histological type of thyroid cancer, the dose of radioiodine used in brackets of 60-150 mCi and additional diseases. Total thyroidectomy is equally efficient as near total. (Pol J Endocrinol 2008; 59 (1): 123-130)
Keywords
thyroid cancer; thyroid remnants; radioiodine; thyroglobulin
Title
The early treatment results of well differentiated thyroid cancer and its dependence on chosen factors
Journal
Issue
Article type
Original paper
Pages
123-130
Published online
2008-05-08
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627
Article views/downloads
1263
Bibliographic record
Endokrynol Pol 2008;59(2):123-130.
Keywords
thyroid cancer
thyroid remnants
radioiodine
thyroglobulin
Authors
Joanna Kłubo-Gwieździńska
Roman Junik