open access

Vol 59, No 2 (2008)
Original papers
Published online: 2008-05-08
Submitted: 2013-02-15
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The early treatment results of well differentiated thyroid cancer and its dependence on chosen factors

Joanna Kłubo-Gwieździńska, Roman Junik
Endokrynologia Polska 2008;59(2):123-130.

open access

Vol 59, No 2 (2008)
Original papers
Published online: 2008-05-08
Submitted: 2013-02-15

Abstract


Introduction: The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.
Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.
Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25.3% (23/91) follicular thyroid cancers, and 6.6% (6/91) oxyphilic thyroid cancers. Among the group, 74 (81.3%) patients reached the remission criteria and the remaining 17 patients (18.7%) showed biochemical and morphological evidence of metastatic disease. The remission was obtained in 100% of patients in stage I of the disease, 68.4% - in stage II, 78.6% - in stage III and 33.3% in stage IV. The total radioiodine dose used in patients with remission, did not differ from the dose used in patients without remission. We did not observe the influence of remnant’s volume on treatment efficacy, however larger remants required higher dose of radioiodine to obtain the remission. Patients with remission had lower postsurgical thyroglobulin concentration than patients without remission. (22.2 vs. 103.3 ng/ml; p = 0.00025).
Conclusions: Early treatment results of well differentiated thyroid cancer depend on the clinical stage, and postoperative serum thyroglobulin level measured after endogenous TSH stimulation. Early treatment results are not dependent on age, sex, histological type of thyroid cancer, the dose of radioiodine used in brackets of 60-150 mCi and additional diseases. Total thyroidectomy is equally efficient as near total. (Pol J Endocrinol 2008; 59 (1): 123-130)

Abstract


Introduction: The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.
Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.
Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25.3% (23/91) follicular thyroid cancers, and 6.6% (6/91) oxyphilic thyroid cancers. Among the group, 74 (81.3%) patients reached the remission criteria and the remaining 17 patients (18.7%) showed biochemical and morphological evidence of metastatic disease. The remission was obtained in 100% of patients in stage I of the disease, 68.4% - in stage II, 78.6% - in stage III and 33.3% in stage IV. The total radioiodine dose used in patients with remission, did not differ from the dose used in patients without remission. We did not observe the influence of remnant’s volume on treatment efficacy, however larger remants required higher dose of radioiodine to obtain the remission. Patients with remission had lower postsurgical thyroglobulin concentration than patients without remission. (22.2 vs. 103.3 ng/ml; p = 0.00025).
Conclusions: Early treatment results of well differentiated thyroid cancer depend on the clinical stage, and postoperative serum thyroglobulin level measured after endogenous TSH stimulation. Early treatment results are not dependent on age, sex, histological type of thyroid cancer, the dose of radioiodine used in brackets of 60-150 mCi and additional diseases. Total thyroidectomy is equally efficient as near total. (Pol J Endocrinol 2008; 59 (1): 123-130)
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Keywords

thyroid cancer; thyroid remnants; radioiodine; thyroglobulin

About this article
Title

The early treatment results of well differentiated thyroid cancer and its dependence on chosen factors

Journal

Endokrynologia Polska

Issue

Vol 59, No 2 (2008)

Pages

123-130

Published online

2008-05-08

Bibliographic record

Endokrynologia Polska 2008;59(2):123-130.

Keywords

thyroid cancer
thyroid remnants
radioiodine
thyroglobulin

Authors

Joanna Kłubo-Gwieździńska
Roman Junik

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