open access

Vol 59, No 3 (2008)
Review article
Published online: 2008-05-08
Submitted: 2013-02-15
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Does type 2 diabetes predispose to osteoporotic bone fractures?

Tomasz Miazgowski, Barbara Krzyżanowska-Świniarska, Jarosław Ogonowski, Marzena Noworyta-Ziętara
Endokrynologia Polska 2008;59(3):224-229.

open access

Vol 59, No 3 (2008)
Review article
Published online: 2008-05-08
Submitted: 2013-02-15

Abstract

Chronic complications of diabetes are associated mainly with changes in major and small arterial vessels as well as in peripheral and autonomic fibers of the nervous system. For years it has been suggested that DM2 does not predispose to osteoporosis because bone mineral density (BMD) in DM2 patients is commonly normal or even increased. However, results of recent large cross-sectional studies have indicated that patients with DM2 have significantly increased risk of bone fractures, predominantly hip fractures (by 70%). Results of these studies suggest that the increased risk of fractures in DM2 is independent of BMD. In this group of patients is frequently associated the loss of vision caused by diabetic eye disease, peripheral neuropathy, arterial hypertension, orthostatic hypotonia (caused by autonomic neuropathy or/and by concomitant antihypertensive treatment), and ischemic disease of the brain, heart and lower extremities - conditions that predispose to falls. There are no specific methods of prophylaxis and treatment of osteoporosis associated with diabetes; therefore they should be based on widely accepted principles as in non-diabetic populations. It seems that in DM2 patients the most purposeful strategy could be the popularization of healthy attitudes aiming the elimination of unfavorable dietetic and environmental factors, such as low physical activity, smoking, and low vitamin D intake, as well as education against falls.

Abstract

Chronic complications of diabetes are associated mainly with changes in major and small arterial vessels as well as in peripheral and autonomic fibers of the nervous system. For years it has been suggested that DM2 does not predispose to osteoporosis because bone mineral density (BMD) in DM2 patients is commonly normal or even increased. However, results of recent large cross-sectional studies have indicated that patients with DM2 have significantly increased risk of bone fractures, predominantly hip fractures (by 70%). Results of these studies suggest that the increased risk of fractures in DM2 is independent of BMD. In this group of patients is frequently associated the loss of vision caused by diabetic eye disease, peripheral neuropathy, arterial hypertension, orthostatic hypotonia (caused by autonomic neuropathy or/and by concomitant antihypertensive treatment), and ischemic disease of the brain, heart and lower extremities - conditions that predispose to falls. There are no specific methods of prophylaxis and treatment of osteoporosis associated with diabetes; therefore they should be based on widely accepted principles as in non-diabetic populations. It seems that in DM2 patients the most purposeful strategy could be the popularization of healthy attitudes aiming the elimination of unfavorable dietetic and environmental factors, such as low physical activity, smoking, and low vitamin D intake, as well as education against falls.
Get Citation

Keywords

diabetes; osteoporosis; bone mineral density

About this article
Title

Does type 2 diabetes predispose to osteoporotic bone fractures?

Journal

Endokrynologia Polska

Issue

Vol 59, No 3 (2008)

Pages

224-229

Published online

2008-05-08

Bibliographic record

Endokrynologia Polska 2008;59(3):224-229.

Keywords

diabetes
osteoporosis
bone mineral density

Authors

Tomasz Miazgowski
Barbara Krzyżanowska-Świniarska
Jarosław Ogonowski
Marzena Noworyta-Ziętara

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