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Vol 59, No 3 (2008)
Case report
Submitted: 2013-02-15
Published online: 2008-05-08
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131I-MIBG therapy in the treatment of pheochromocytoma in children - own experiences

Kornelia Hasse-Lazar, Jolanta Krajewska, Ewa Paliczka-Cieślik, Beata Jurecka-Lubieniecka, Barbara Michalik, Daria Handkiewicz-Junak, Józef Roskosz, Barbara Jarząb
Endokrynol Pol 2008;59(3):235-240.

open access

Vol 59, No 3 (2008)
Case report
Submitted: 2013-02-15
Published online: 2008-05-08

Abstract

Three cases of pheochromocytoma in children/adolescents or young adults treated by 131I-MIBG are presented in this study. In one patient 131I-MIBG was administrated after ineffective surgical treatment and chemotherapy of a benign retroperitoneal tumor, whereas in two other patients 131I-MIBG therapy was carried out because of malignant pheochromocytoma dissemination. In a child with retroperitoneal paraganglioma decrease of tumor size and its fibrosis after 131I-MIBG therapy allowed radical surgery and complete recovery. In two other cases partial remission was achieved. All patients showed a good subjective response with improvement of the general condition and better blood pressure control. In two children adverse reactions such as leucopenia, hypothyroidism or hypogonadism were observed. The presented data confirm effectiveness and acceptable tolerance of 131I-MIBG treatment in pheochromocytoma, what is very important in pediatric patients.

Abstract

Three cases of pheochromocytoma in children/adolescents or young adults treated by 131I-MIBG are presented in this study. In one patient 131I-MIBG was administrated after ineffective surgical treatment and chemotherapy of a benign retroperitoneal tumor, whereas in two other patients 131I-MIBG therapy was carried out because of malignant pheochromocytoma dissemination. In a child with retroperitoneal paraganglioma decrease of tumor size and its fibrosis after 131I-MIBG therapy allowed radical surgery and complete recovery. In two other cases partial remission was achieved. All patients showed a good subjective response with improvement of the general condition and better blood pressure control. In two children adverse reactions such as leucopenia, hypothyroidism or hypogonadism were observed. The presented data confirm effectiveness and acceptable tolerance of 131I-MIBG treatment in pheochromocytoma, what is very important in pediatric patients.

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Keywords

Pheochromocytoma; 131I-MIBG therapy; children

About this article
Title

131I-MIBG therapy in the treatment of pheochromocytoma in children - own experiences

Journal

Endokrynologia Polska

Issue

Vol 59, No 3 (2008)

Article type

Case report

Pages

235-240

Published online

2008-05-08

Page views

731

Article views/downloads

2805

Bibliographic record

Endokrynol Pol 2008;59(3):235-240.

Keywords

Pheochromocytoma
131I-MIBG therapy
children

Authors

Kornelia Hasse-Lazar
Jolanta Krajewska
Ewa Paliczka-Cieślik
Beata Jurecka-Lubieniecka
Barbara Michalik
Daria Handkiewicz-Junak
Józef Roskosz
Barbara Jarząb

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