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Ghrelin as a potential blood pressure reducing factor in obese women during weight loss treatment
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Abstract
Material and methods: A group of 37 obese premenopausal women with no previous history of hypertension (BMI: 36.5 ± 5 kg/m2) were involved in the study. Blood pressure and serum ghrelin levels were assessed before and after a three-month weight reduction treatment, which consisted of a diet of 1000 kcal/day and physical exercise. Body composition was determined by impedance analysis using Bodystat.
Results: Following weight loss (mean 8.9 ± 4.8 kg) SBP decreased (120 ± 13 vs. 115 ± 14 mm Hg, p = 0.01) and serum ghrelin levels increased significantly (66.9 ± 13.7 vs. 73.9 ± 15.4 pg/ml; p = 0.005). There were significant correlations between values for ghrelin levels after weight loss and SBP (r = -0.45, p = 0.02), DBP (r = -0.41, p < 0.05), and between Dghrelin levels and DSBP (r = 0.52, p = 0.006), DDBP (r = 0.53, p = 0.005). There was a positive correlation between an increase in ghrelin and a decrease in percentage body fat during weight loss (r = 0.51; p = 0.002).
Conclusion: The results seem to provide evidence that weight loss may decrease blood pressure in obese patients via a ghrelin-dependent mechanism.
Abstract
Material and methods: A group of 37 obese premenopausal women with no previous history of hypertension (BMI: 36.5 ± 5 kg/m2) were involved in the study. Blood pressure and serum ghrelin levels were assessed before and after a three-month weight reduction treatment, which consisted of a diet of 1000 kcal/day and physical exercise. Body composition was determined by impedance analysis using Bodystat.
Results: Following weight loss (mean 8.9 ± 4.8 kg) SBP decreased (120 ± 13 vs. 115 ± 14 mm Hg, p = 0.01) and serum ghrelin levels increased significantly (66.9 ± 13.7 vs. 73.9 ± 15.4 pg/ml; p = 0.005). There were significant correlations between values for ghrelin levels after weight loss and SBP (r = -0.45, p = 0.02), DBP (r = -0.41, p < 0.05), and between Dghrelin levels and DSBP (r = 0.52, p = 0.006), DDBP (r = 0.53, p = 0.005). There was a positive correlation between an increase in ghrelin and a decrease in percentage body fat during weight loss (r = 0.51; p = 0.002).
Conclusion: The results seem to provide evidence that weight loss may decrease blood pressure in obese patients via a ghrelin-dependent mechanism.
Keywords
obesity; ghrelin; arterial blood pressure; weight loss
About this articleTitle
Ghrelin as a potential blood pressure reducing factor in obese women during weight loss treatment
Journal
Issue
Article type
Original paper
Pages
207-211
Published online
2008-05-08
Page views
669
Article views/downloads
1042
Bibliographic record
Endokrynol Pol 2008;59(3):207-211.
Keywords
obesity
ghrelin
arterial blood pressure
weight loss
Authors
Katarzyna Mizia-Stec
Barbara Zahorska-Markiewicz
Magdalena Olszanecka-Glinianowicz
Joanna Janowska
Zbigniew Mucha
Michał Holecki
Zbigniew Gąsior
