open access
Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas
open access
Abstract
According to presented papers mRNA expression of analyzed genes is best known in tissue obtained from tumours excised from patients with Conn syndrome. On the other hand transcriptional activity of the genes within the other adrenocortical adenomas is documented in lesser degree. It concerns particularly analyses of tissue material obtained from patients, in which hormonal activity of adrenal tumours was not confirmed with biochemical tests.
It should be also considered, that the frame of reference for the majority of molecular analyses of adrenocortical tumour tissues was material obtained from little number of normal adrenals, what decreases in some degree credibility of obtained results. Mentioned above remarks may be the basis for conduction of further investigations based on larger material, obtained both from normal adrenals and adrenocortical adenomas.
Abstract
According to presented papers mRNA expression of analyzed genes is best known in tissue obtained from tumours excised from patients with Conn syndrome. On the other hand transcriptional activity of the genes within the other adrenocortical adenomas is documented in lesser degree. It concerns particularly analyses of tissue material obtained from patients, in which hormonal activity of adrenal tumours was not confirmed with biochemical tests.
It should be also considered, that the frame of reference for the majority of molecular analyses of adrenocortical tumour tissues was material obtained from little number of normal adrenals, what decreases in some degree credibility of obtained results. Mentioned above remarks may be the basis for conduction of further investigations based on larger material, obtained both from normal adrenals and adrenocortical adenomas.
Keywords
adrenal cortex; adrenocortical adenoma; aldosterone; cortisol; Conn syndrome; Cushing syndrome; expression; mRNA; gene
Title
Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas
Journal
Issue
Article type
Review paper
Pages
330-339
Published online
2008-07-09
Page views
634
Article views/downloads
7750
Bibliographic record
Endokrynol Pol 2008;59(4):330-339.
Keywords
adrenal cortex
adrenocortical adenoma
aldosterone
cortisol
Conn syndrome
Cushing syndrome
expression
mRNA
gene
Authors
Jacek Ziaja
Krzysztof Cholewa
Urszula Mazurek
Lech Cierpka