open access

Vol 59, No 4 (2008)
Original papers
Published online: 2008-07-09
Submitted: 2013-02-15
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The effect of weight reduction on plasma concentrations of ghrelin and insulin-like growth factor 1 in obese women

Magdalena Olszanecka-Glinianowicz, Barbara Zahorska-Markiewicz, Piotr Kocełak, Joanna Janowska, Elżbieta Semik-Grabarczyk
Endokrynologia Polska 2008;59(4):301-304.

open access

Vol 59, No 4 (2008)
Original papers
Published online: 2008-07-09
Submitted: 2013-02-15

Abstract


Introduction: The aim of the present study was to examine how weight loss treatment modulates plasma concentrations of ghrelin and insulin-like growth factor 1 (IGF-1) in obese women and to determine whether there is any association with possible changes in plasma concentrations of these hormones after weight loss.
Material and methods: The study group consisted of 22 obese women without additional disease (age 40.6 ± 12.9 years; BMI 37.2 ± 4.6 kg/m2). All subjects participated in a 3-month weight reduction program. The measurements were performed at baseline and after weight loss. Plasma concentration of ghrelin and IGF-1 were measured by enzyme – linked immunosorbent assay (ELISA) kit. Serum concentrations of insulin were measured by radioimmunoassay (RIA). Body composition was determined by bioelectrical impedance analysis using a Bodystat analyser.
Results: The mean weight loss was 9.3 &#177; 4.1 kg (9.7 &#177; 4.3%). Following weight loss, plasma ghrelin and IGF-1 concentrations increased significantly (63.5 &#177; 13.0 vs. 72.8 &#177; 15.1 pg/ml; p < 0.01; 126.9 &#177; 67.0 vs. 170.5 &#177; 83.3 ng/ml p < 0.01, respectively) and serum insulin concentrations decreased significantly (17.5 &#177; 8.5 vs. 14.8 &#177; 10.4 mIU/ml p< 0.05). We observed a significant positive correlation between the increase of ghrelin and decrease of body fat percentage after weight loss (r = 0.44, p = 0.03). There are no correlations between change of ghrelin and IGF-1concentrations and between changes of insulin and IGF 1 concentrations.
Conclusion: Plasma concentrations of ghrelin and IGF-1 increased after weight loss. However, it seems there is no association between serum concentrations of ghrelin and IGF-1 in obese women.

Abstract


Introduction: The aim of the present study was to examine how weight loss treatment modulates plasma concentrations of ghrelin and insulin-like growth factor 1 (IGF-1) in obese women and to determine whether there is any association with possible changes in plasma concentrations of these hormones after weight loss.
Material and methods: The study group consisted of 22 obese women without additional disease (age 40.6 &#177; 12.9 years; BMI 37.2 &#177; 4.6 kg/m2). All subjects participated in a 3-month weight reduction program. The measurements were performed at baseline and after weight loss. Plasma concentration of ghrelin and IGF-1 were measured by enzyme &#8211; linked immunosorbent assay (ELISA) kit. Serum concentrations of insulin were measured by radioimmunoassay (RIA). Body composition was determined by bioelectrical impedance analysis using a Bodystat analyser.
Results: The mean weight loss was 9.3 &#177; 4.1 kg (9.7 &#177; 4.3%). Following weight loss, plasma ghrelin and IGF-1 concentrations increased significantly (63.5 &#177; 13.0 vs. 72.8 &#177; 15.1 pg/ml; p < 0.01; 126.9 &#177; 67.0 vs. 170.5 &#177; 83.3 ng/ml p < 0.01, respectively) and serum insulin concentrations decreased significantly (17.5 &#177; 8.5 vs. 14.8 &#177; 10.4 mIU/ml p< 0.05). We observed a significant positive correlation between the increase of ghrelin and decrease of body fat percentage after weight loss (r = 0.44, p = 0.03). There are no correlations between change of ghrelin and IGF-1concentrations and between changes of insulin and IGF 1 concentrations.
Conclusion: Plasma concentrations of ghrelin and IGF-1 increased after weight loss. However, it seems there is no association between serum concentrations of ghrelin and IGF-1 in obese women.
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Keywords

obesity; ghrelin; IGF-1; weight loss

About this article
Title

The effect of weight reduction on plasma concentrations of ghrelin and insulin-like growth factor 1 in obese women

Journal

Endokrynologia Polska

Issue

Vol 59, No 4 (2008)

Pages

301-304

Published online

2008-07-09

Bibliographic record

Endokrynologia Polska 2008;59(4):301-304.

Keywords

obesity
ghrelin
IGF-1
weight loss

Authors

Magdalena Olszanecka-Glinianowicz
Barbara Zahorska-Markiewicz
Piotr Kocełak
Joanna Janowska
Elżbieta Semik-Grabarczyk

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