open access

Vol 59, No 5 (2008)
Case report
Published online: 2008-09-26
Submitted: 2013-02-15
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Used of oral antidiabetic agents in pediatric patients - own observations

Joanna Stańczyk, Ewa Otto-Buczkowska, Przemysława Jarosz-Chobot, Bożena Nowowiejska
Endokrynologia Polska 2008;59(5):434-442.

open access

Vol 59, No 5 (2008)
Case report
Published online: 2008-09-26
Submitted: 2013-02-15

Abstract

Our present investigation demonstrates that in adolescents with various impaired glucose homeostasis oral antidiabetic agents can be used to improve glucose metabolism. Metformin is widely used in pediatric patients and is considered to be the most effective oral agent. Metformin is beneficial in improving glucose tolerance and insulin sensitivity, in lowering insulinemia, and in reducing elevated androgen levels. Addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus improves metabolic control. Metformin acts by promoting glucose utilization and reducing hepatic glucose production. In many patients with type 2 diabetes, hyperglycemia can be reduced with appropriate changes in diet and exercise, however, some patients with type 2 diabetes and insulin resistance syndromes need pharmacological therapy to improve their metabolic control. The first oral agent concerned to use should be metformin. More severe pancreatic b-cell dysfunction in the group of children requires insulin therapy. Some forms of monogenic diabetes can be successfully managed by sulphonylurea agents. Metformin should be considered a first-line agent in girls with PCOS. (Pol J Endocrinol 2008; 59 (5): 434-443)

Abstract

Our present investigation demonstrates that in adolescents with various impaired glucose homeostasis oral antidiabetic agents can be used to improve glucose metabolism. Metformin is widely used in pediatric patients and is considered to be the most effective oral agent. Metformin is beneficial in improving glucose tolerance and insulin sensitivity, in lowering insulinemia, and in reducing elevated androgen levels. Addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus improves metabolic control. Metformin acts by promoting glucose utilization and reducing hepatic glucose production. In many patients with type 2 diabetes, hyperglycemia can be reduced with appropriate changes in diet and exercise, however, some patients with type 2 diabetes and insulin resistance syndromes need pharmacological therapy to improve their metabolic control. The first oral agent concerned to use should be metformin. More severe pancreatic b-cell dysfunction in the group of children requires insulin therapy. Some forms of monogenic diabetes can be successfully managed by sulphonylurea agents. Metformin should be considered a first-line agent in girls with PCOS. (Pol J Endocrinol 2008; 59 (5): 434-443)
Get Citation

Keywords

impaired glucose tolerance; diabetes; insulin resistance; oral antidiabetic agents; metabolic control

About this article
Title

Used of oral antidiabetic agents in pediatric patients - own observations

Journal

Endokrynologia Polska

Issue

Vol 59, No 5 (2008)

Pages

434-442

Published online

2008-09-26

Bibliographic record

Endokrynologia Polska 2008;59(5):434-442.

Keywords

impaired glucose tolerance
diabetes
insulin resistance
oral antidiabetic agents
metabolic control

Authors

Joanna Stańczyk
Ewa Otto-Buczkowska
Przemysława Jarosz-Chobot
Bożena Nowowiejska

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