open access

Vol 59, No 5 (2008)
Original papers
Published online: 2008-09-26
Submitted: 2013-02-15
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Gestational diabetes mellitus - an analysis of risk factors

Katarzyna Cypryk, Wiesław Szymczak, Leszek Czupryniak, Małgorzata Sobczak, Andrzej Lewiński
Endokrynologia Polska 2008;59(5):393-397.

open access

Vol 59, No 5 (2008)
Original papers
Published online: 2008-09-26
Submitted: 2013-02-15

Abstract


Introduction: Gestational diabetes mellitus (GDM) is associated with an increased frequency of gestational, perinatal and neonatal complications. The aim of the study was to evaluate risk factors for GDM and their predictive value.
Material and methods: The group studied consisted of 510 pregnant women with GDM diagnosed according to World Health Organization (WHO) criteria (GDM). The controls were 1160 pregnant women with normal glucose tolerance (NGT). Multifactorial analysis was performed and odds ratios (OR) were calculated for each risk factor identified.
Results: The GDM patients were significantly older than the NGT subjects (30.1 vs. 27.2 years; p < 0.0001), had a greater tendency towards obesity before pregnancy (BMI 25.0 vs. 21.6 kg/m2; p < 0.0001), more often had relatives with diabetes (40.0 vs. 25.7%; p < 0.01), had greater parity (third or subsequent pregnancy: 33.6 vs. 16.0%; p < 0.001) and more often experienced adverse perinatal outcomes (21.4 vs. 13.7%; p < 0.01). Multivariate analysis revealed the following risk factors for GDM: BMI > 25 kg/m2 25 years (OR 1.34). No risk factors were present in 12% of GDM subjects, and at least one risk factor was found in 74.1% of subjects with NGT. No risk factor cluster was found which could be used easily in everyday practice to identify reliably subjects at increased risk of GDM.
Conclusions: Age, overweight and obesity, diabetes in the family, parity, macrosomia and a history of perinatal complications were identified as risk factors for GDM. As no reliable method of identifying subjects at increased GDM risk was found, we suggest that all pregnant women should undergo laboratory screening for GDM. (Pol J Endocrinol 2008; 59 (5): 393-397)

Abstract


Introduction: Gestational diabetes mellitus (GDM) is associated with an increased frequency of gestational, perinatal and neonatal complications. The aim of the study was to evaluate risk factors for GDM and their predictive value.
Material and methods: The group studied consisted of 510 pregnant women with GDM diagnosed according to World Health Organization (WHO) criteria (GDM). The controls were 1160 pregnant women with normal glucose tolerance (NGT). Multifactorial analysis was performed and odds ratios (OR) were calculated for each risk factor identified.
Results: The GDM patients were significantly older than the NGT subjects (30.1 vs. 27.2 years; p < 0.0001), had a greater tendency towards obesity before pregnancy (BMI 25.0 vs. 21.6 kg/m2; p < 0.0001), more often had relatives with diabetes (40.0 vs. 25.7%; p < 0.01), had greater parity (third or subsequent pregnancy: 33.6 vs. 16.0%; p < 0.001) and more often experienced adverse perinatal outcomes (21.4 vs. 13.7%; p < 0.01). Multivariate analysis revealed the following risk factors for GDM: BMI > 25 kg/m2 25 years (OR 1.34). No risk factors were present in 12% of GDM subjects, and at least one risk factor was found in 74.1% of subjects with NGT. No risk factor cluster was found which could be used easily in everyday practice to identify reliably subjects at increased risk of GDM.
Conclusions: Age, overweight and obesity, diabetes in the family, parity, macrosomia and a history of perinatal complications were identified as risk factors for GDM. As no reliable method of identifying subjects at increased GDM risk was found, we suggest that all pregnant women should undergo laboratory screening for GDM. (Pol J Endocrinol 2008; 59 (5): 393-397)
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Keywords

gestational diabetes mellitus; screening; risk factor

About this article
Title

Gestational diabetes mellitus - an analysis of risk factors

Journal

Endokrynologia Polska

Issue

Vol 59, No 5 (2008)

Pages

393-397

Published online

2008-09-26

Bibliographic record

Endokrynologia Polska 2008;59(5):393-397.

Keywords

gestational diabetes mellitus
screening
risk factor

Authors

Katarzyna Cypryk
Wiesław Szymczak
Leszek Czupryniak
Małgorzata Sobczak
Andrzej Lewiński

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