open access

Vol 59, No 5 (2008)
Original papers
Published online: 2008-09-26
Submitted: 2013-02-15
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The relationship between serum concentration of free testosterone and pre-eclampsia

Valentina Ghorashi, Mehrdad Sheikhvatan
Endokrynologia Polska 2008;59(5):390-392.

open access

Vol 59, No 5 (2008)
Original papers
Published online: 2008-09-26
Submitted: 2013-02-15

Abstract

Introduction: Hyperandrogenism may be implicated in the pathogenesis of pre-eclampsia. We hypothesised that there may be a difference between the levels of testosterone in pregnant women complicated with pre-eclampsia and those of matched women without this complication.
Material and methods: A case-control study conducted in Tehran, Iran between January and June 2006 included 20 women with moderate to severe pre-eclampsia and 20 normotensive pregnant women without complications who were matched for age, body mass index and gravity. Maternal levels of free testosterone was measured in the two groups and compared.
Results: Free testosterone levels were significantly higher in the pre-eclamptic group (mean = 1.97, SD = 0.58, median = 1.90 ng/dL) than in the control group (mean = 0.58, SD = 0.29, median=0.50 ng/dL) (P < 0.001).
Conclusions: An increase in serum free testosterone concentration may be considered an important risk factor for pre-eclampsia and might be implicated in the pathogenesis of pre-eclampsia. (Pol J Endocrinol 2008; 59 (5): 390-392)

Abstract

Introduction: Hyperandrogenism may be implicated in the pathogenesis of pre-eclampsia. We hypothesised that there may be a difference between the levels of testosterone in pregnant women complicated with pre-eclampsia and those of matched women without this complication.
Material and methods: A case-control study conducted in Tehran, Iran between January and June 2006 included 20 women with moderate to severe pre-eclampsia and 20 normotensive pregnant women without complications who were matched for age, body mass index and gravity. Maternal levels of free testosterone was measured in the two groups and compared.
Results: Free testosterone levels were significantly higher in the pre-eclamptic group (mean = 1.97, SD = 0.58, median = 1.90 ng/dL) than in the control group (mean = 0.58, SD = 0.29, median=0.50 ng/dL) (P < 0.001).
Conclusions: An increase in serum free testosterone concentration may be considered an important risk factor for pre-eclampsia and might be implicated in the pathogenesis of pre-eclampsia. (Pol J Endocrinol 2008; 59 (5): 390-392)
Get Citation

Keywords

testosterone; pre-eclampsia; pathogenesis; pregnancy

About this article
Title

The relationship between serum concentration of free testosterone and pre-eclampsia

Journal

Endokrynologia Polska

Issue

Vol 59, No 5 (2008)

Pages

390-392

Published online

2008-09-26

Bibliographic record

Endokrynologia Polska 2008;59(5):390-392.

Keywords

testosterone
pre-eclampsia
pathogenesis
pregnancy

Authors

Valentina Ghorashi
Mehrdad Sheikhvatan

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