Vol 59, No 6 (2008)
Review paper
Published online: 2008-10-30
The role of growth hormone and insulin-like growth factor I in oxidative processes
Endokrynol Pol 2008;59(6):496-501.
Abstract
Under physiological conditions, there is a balance between the production and detoxification of reactive oxygen species (ROS). In the
course of several diseases, an overproduction of ROS and their increased reaction with biological macromolecules, lead to disruption of
this balance and to enhanced oxidative stress. Alterations in growth hormone (GH)/insulin-like growth factor I (IGF-I) pathway (e.g., in
condition of GH overproduction or deficiency) are tightly linked with enhanced oxidative stress.
The results of experimental and clinical studies, in which effects of GH and IGF-I on oxidative processes were revealed, are presented in
the survey.
Keywords: hormon wzrostuinsulinopodobny czynnik wzrostu Istres oksydacyjnyperoksydacja lipidówniedobór hormonu wzrostuakromegalia
![](https://journals.viamedica.pl/plugins/generic/popups/images/icons/close.png)