open access

Vol 59, No 6 (2008)
Review article
Published online: 2008-10-30
Submitted: 2013-02-15
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The role of growth hormone and insulin-like growth factor I in oxidative processes

Agnieszka Kokoszko, Andrzej Lewiński, Małgorzata Karbownik-Lewińska
Endokrynologia Polska 2008;59(6):496-501.

open access

Vol 59, No 6 (2008)
Review article
Published online: 2008-10-30
Submitted: 2013-02-15

Abstract

Under physiological conditions, there is a balance between the production and detoxification of reactive oxygen species (ROS). In the course of several diseases, an overproduction of ROS and their increased reaction with biological macromolecules, lead to disruption of this balance and to enhanced oxidative stress. Alterations in growth hormone (GH)/insulin-like growth factor I (IGF-I) pathway (e.g., in condition of GH overproduction or deficiency) are tightly linked with enhanced oxidative stress. The results of experimental and clinical studies, in which effects of GH and IGF-I on oxidative processes were revealed, are presented in the survey.

Abstract

Under physiological conditions, there is a balance between the production and detoxification of reactive oxygen species (ROS). In the course of several diseases, an overproduction of ROS and their increased reaction with biological macromolecules, lead to disruption of this balance and to enhanced oxidative stress. Alterations in growth hormone (GH)/insulin-like growth factor I (IGF-I) pathway (e.g., in condition of GH overproduction or deficiency) are tightly linked with enhanced oxidative stress. The results of experimental and clinical studies, in which effects of GH and IGF-I on oxidative processes were revealed, are presented in the survey.
Get Citation

Keywords

hormon wzrostu; insulinopodobny czynnik wzrostu I; stres oksydacyjny; peroksydacja lipidów; niedobór hormonu wzrostu; akromegalia

About this article
Title

The role of growth hormone and insulin-like growth factor I in oxidative processes

Journal

Endokrynologia Polska

Issue

Vol 59, No 6 (2008)

Pages

496-501

Published online

2008-10-30

Bibliographic record

Endokrynologia Polska 2008;59(6):496-501.

Keywords

hormon wzrostu
insulinopodobny czynnik wzrostu I
stres oksydacyjny
peroksydacja lipidów
niedobór hormonu wzrostu
akromegalia

Authors

Agnieszka Kokoszko
Andrzej Lewiński
Małgorzata Karbownik-Lewińska

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