open access

Vol 59, No 6 (2008)
Original papers
Published online: 2008-10-30
Submitted: 2013-02-15
Get Citation

Serum concentration of 1-84 (cyclase-activating) and 7-84 (cyclase-inhibiting) parathormone in elderly women with low mineral density of the trabecular bone

Edward Franek, Iwona Piwowarska, Maciej Bułanowski, Franciszek Kokot, Andrzej Więcek
Endokrynologia Polska 2008;59(6):471-476.

open access

Vol 59, No 6 (2008)
Original papers
Published online: 2008-10-30
Submitted: 2013-02-15

Abstract


Introduction: Ageing may cause an increase in parathormone (PTH) secretion and, subsequently, increased bone resorption and osteoporosis. In recent years two subfractions of PTH have been discovered: cyclase-activating (1-84, CAP) and cyclase-inhibiting (7-84, CIP) PTH. It is not known however, whether these may play a role in the pathogenesis of bone loss in elderly subjects.
Material and methods: Sixty elderly women were examined, of whom 29 had a T-score of the ultradistal radius < -2.5 (median age 75 [70-80] years, BMI 25 [20.6-33.8] kg/m2, creatinine clearance 59.9 [39.2-94.9] ml/min/1.73m2 -2.5 (median age 73 [70-86] years, BMI 26.2 [18.8-32.5] kg/m2, creatinine clearance 54.8 [23-119.2] ml/min/1.73m2, serum Ca 2.4 [2.2-2.6] mmol/l). Median bone mineral density (BMD) (DXA, Lunar) of the ultradistal radius was 0.263 (0.195-0.449) g/cm2 and 0.326 (0.236-0.448) g/cm2 (p < 0.0001), with a median T-score of -3.48 and -1.4, respectively. Each patient with a serum concentration of 1-84 and 7-84 PTH was assessed.
Results: Patients with low BMD did not differ from those with higher BMD with regard to serum iPTH (16 [6-51] vs. 11.5 [7-35] pg/ml, p = 0.066) and CIP (6 [1&#8211;14] vs. 4.5 [2-13] pg/ml) concentrations. However, serum CAP concentrations (10.5 [4&#8211;41] vs. 6 [4-22] pg/ml, p < 0.05) and CAP/CIP ratios (2.0 [0.71&#8211;11] vs. 1.25 [0.5-4.2], p < 0.05) were significantly higher in the low BMD group.
Conclusion: In elderly women increased serum CAP concentrations and CAP/CIP ratios are associated with low BMD of the trabecular bone.

Abstract


Introduction: Ageing may cause an increase in parathormone (PTH) secretion and, subsequently, increased bone resorption and osteoporosis. In recent years two subfractions of PTH have been discovered: cyclase-activating (1-84, CAP) and cyclase-inhibiting (7-84, CIP) PTH. It is not known however, whether these may play a role in the pathogenesis of bone loss in elderly subjects.
Material and methods: Sixty elderly women were examined, of whom 29 had a T-score of the ultradistal radius < -2.5 (median age 75 [70-80] years, BMI 25 [20.6-33.8] kg/m2, creatinine clearance 59.9 [39.2-94.9] ml/min/1.73m2 -2.5 (median age 73 [70-86] years, BMI 26.2 [18.8-32.5] kg/m2, creatinine clearance 54.8 [23-119.2] ml/min/1.73m2, serum Ca 2.4 [2.2-2.6] mmol/l). Median bone mineral density (BMD) (DXA, Lunar) of the ultradistal radius was 0.263 (0.195-0.449) g/cm2 and 0.326 (0.236-0.448) g/cm2 (p < 0.0001), with a median T-score of -3.48 and -1.4, respectively. Each patient with a serum concentration of 1-84 and 7-84 PTH was assessed.
Results: Patients with low BMD did not differ from those with higher BMD with regard to serum iPTH (16 [6-51] vs. 11.5 [7-35] pg/ml, p = 0.066) and CIP (6 [1&#8211;14] vs. 4.5 [2-13] pg/ml) concentrations. However, serum CAP concentrations (10.5 [4&#8211;41] vs. 6 [4-22] pg/ml, p < 0.05) and CAP/CIP ratios (2.0 [0.71&#8211;11] vs. 1.25 [0.5-4.2], p < 0.05) were significantly higher in the low BMD group.
Conclusion: In elderly women increased serum CAP concentrations and CAP/CIP ratios are associated with low BMD of the trabecular bone.
Get Citation

Keywords

Parathormone; 1-84 PTH; 7-84 PTH; osteoporosis; bone

About this article
Title

Serum concentration of 1-84 (cyclase-activating) and 7-84 (cyclase-inhibiting) parathormone in elderly women with low mineral density of the trabecular bone

Journal

Endokrynologia Polska

Issue

Vol 59, No 6 (2008)

Pages

471-476

Published online

2008-10-30

Bibliographic record

Endokrynologia Polska 2008;59(6):471-476.

Keywords

Parathormone
1-84 PTH
7-84 PTH
osteoporosis
bone

Authors

Edward Franek
Iwona Piwowarska
Maciej Bułanowski
Franciszek Kokot
Andrzej Więcek

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl