open access

Vol 60, No 1 (2009)
Postgraduate education
Published online: 2008-12-19
Submitted: 2013-02-15
Get Citation

Testosterone metabolism and doping test results

Łukasz Łaczmański, Marek Mędraś
Endokrynologia Polska 2009;60(1):58-62.

open access

Vol 60, No 1 (2009)
Postgraduate education
Published online: 2008-12-19
Submitted: 2013-02-15

Abstract

Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: UGT2B7, UGT2B15 and UGT2B17. Glucuronide products are more polar, water soluble, less toxic and easily extracted form the body.
Testosterone is a common androgen abused in sport. The norm for urinary testosterone/epitestosterone ratio is below 4.0. Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ratio level.

Abstract

Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: UGT2B7, UGT2B15 and UGT2B17. Glucuronide products are more polar, water soluble, less toxic and easily extracted form the body.
Testosterone is a common androgen abused in sport. The norm for urinary testosterone/epitestosterone ratio is below 4.0. Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ratio level.
Get Citation

Keywords

doping; glucuronidation; UDP-glucuronosyltransferase; androgen; testosterone; epitestosterone

About this article
Title

Testosterone metabolism and doping test results

Journal

Endokrynologia Polska

Issue

Vol 60, No 1 (2009)

Pages

58-62

Published online

2008-12-19

Bibliographic record

Endokrynologia Polska 2009;60(1):58-62.

Keywords

doping
glucuronidation
UDP-glucuronosyltransferase
androgen
testosterone
epitestosterone

Authors

Łukasz Łaczmański
Marek Mędraś

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl