open access
Relationship between toxic effects of potassium bromate and endocrine glands
open access
Abstract
KBrO3 induces oxidative stress and may contribute to neoplasia in endocrine glands. It has been demonstrated that KBrO3 triggers thyroid follicular cell tumors in rats. It has been revealed in our in vivo and in vitro studies that KBrO3 significantly increases lipid peroxidation in rat and porcine thyroid. KBrO3 also induces mesotheliomas which may secrete hormones or similar substances, such as parathyroid hormone related protein, phosphatonins or melanocyte stimulating hormone.
In our experimental studies we demonstrated that antioxidants, such as pineal hormone - melatonin, indole-3-propionic acid (IPA) (a compound chemically and physically similar to melatonin) and antythyroid drug - propylthiouracil (PTU), produce distinct protective effects against lipid peroxidation due to KBrO3 in the thyroid in vivo.
KBrO3 is a prooxidant which may induce neoplasia in endocrine glands and cause hormonal disturbances, however its damaging effects may be neutralized by hormones, mainly melatonin.
Abstract
KBrO3 induces oxidative stress and may contribute to neoplasia in endocrine glands. It has been demonstrated that KBrO3 triggers thyroid follicular cell tumors in rats. It has been revealed in our in vivo and in vitro studies that KBrO3 significantly increases lipid peroxidation in rat and porcine thyroid. KBrO3 also induces mesotheliomas which may secrete hormones or similar substances, such as parathyroid hormone related protein, phosphatonins or melanocyte stimulating hormone.
In our experimental studies we demonstrated that antioxidants, such as pineal hormone - melatonin, indole-3-propionic acid (IPA) (a compound chemically and physically similar to melatonin) and antythyroid drug - propylthiouracil (PTU), produce distinct protective effects against lipid peroxidation due to KBrO3 in the thyroid in vivo.
KBrO3 is a prooxidant which may induce neoplasia in endocrine glands and cause hormonal disturbances, however its damaging effects may be neutralized by hormones, mainly melatonin.
Keywords
potassium bromate; oxidative stress; melatonin; endocrine glands; thyroid gland; hormones
About this articleTitle
Relationship between toxic effects of potassium bromate and endocrine glands
Journal
Issue
Article type
Review paper
Pages
40-50
Published online
2008-12-19
Page views
624
Article views/downloads
2001
DOI
10.5603/ep.25507
Bibliographic record
Endokrynol Pol 2009;60(1):40-50.
Keywords
potassium bromate
oxidative stress
melatonin
endocrine glands
thyroid gland
hormones
Authors
Magdalena Stasiak
Andrzej Lewiński
Małgorzata Karbownik-Lewińska
