open access

Vol 60, No 1 (2009)
Case report
Published online: 2008-12-19
Submitted: 2013-02-15
Get Citation

Inhibitory effect of carbamazepine on hypotensive action of spironolactone in primary aldosteronism

Robert Krysiak, Bogdan Marek, Bogusław Okopień
Endokrynologia Polska 2009;60(1):52-55.

open access

Vol 60, No 1 (2009)
Case report
Published online: 2008-12-19
Submitted: 2013-02-15

Abstract

Despite progress made in recent years, interactions between various drugs are far from being fully understood. Moreover, a peculiarity of constitution causes that some individuals in particular situations respond differently to a drug or treatment than do most people. We report the case of a 68-year-old female with primary aldosteronism treated with spironolactone. The patient occasionally suffered from trigeminal neuralgia and was then prescribed with carbamazepine, which although alleviated pain worsened the control of blood pressure. To maintain blood pressure within normal limits the doses of spironolactone had to be increased. Replacement of carbamazepine with gabapentin prevented these drug-induced increases in blood pressure in our patient. This case shows for the first time the existence of a drug interaction between spironolactone and any anti-epileptic drug in primary aldosteronism.

Abstract

Despite progress made in recent years, interactions between various drugs are far from being fully understood. Moreover, a peculiarity of constitution causes that some individuals in particular situations respond differently to a drug or treatment than do most people. We report the case of a 68-year-old female with primary aldosteronism treated with spironolactone. The patient occasionally suffered from trigeminal neuralgia and was then prescribed with carbamazepine, which although alleviated pain worsened the control of blood pressure. To maintain blood pressure within normal limits the doses of spironolactone had to be increased. Replacement of carbamazepine with gabapentin prevented these drug-induced increases in blood pressure in our patient. This case shows for the first time the existence of a drug interaction between spironolactone and any anti-epileptic drug in primary aldosteronism.
Get Citation

Keywords

carbamazepine; spironolactone; drug interactions; antihypertensive effect; primary aldosteronism

About this article
Title

Inhibitory effect of carbamazepine on hypotensive action of spironolactone in primary aldosteronism

Journal

Endokrynologia Polska

Issue

Vol 60, No 1 (2009)

Pages

52-55

Published online

2008-12-19

Bibliographic record

Endokrynologia Polska 2009;60(1):52-55.

Keywords

carbamazepine
spironolactone
drug interactions
antihypertensive effect
primary aldosteronism

Authors

Robert Krysiak
Bogdan Marek
Bogusław Okopień

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl