Vol 60, No 2 (2009)
Review paper
Published online: 2009-03-27
Mechanisms of action of anticatabolic drugs used in osteoporosis therapy
Endokrynol Pol 2009;60(2):134-144.
Abstract
Bone remodeling is essential for skeletal and the whole body health. Imbalance in skeletal turnover, so that bone resorption exceeds bone
formation, may lead to reduction in bone strength and increase fractures risk. The main target of anticatabolic therapy is to normalize
increased osteoclasts activity and bone turnover. Molecular mechanisms of action of this class of drugs are related with different points in
cellular signaling pathways that control osteoclasts differentiation and resorbing activity. These mechanisms are briefly described in our
review.
Keywords: mechanism of actionanticatabolic therapybone resorptionosteoclastosteoporosis
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