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Vol 60, No 2 (2009)
Review paper
Submitted: 2013-02-15
Published online: 2009-03-27
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Mechanisms of action of anticatabolic drugs used in osteoporosis therapy

Edyta Kryśkiewicz, Roman S. Lorenc
DOI: 10.5603/ep.25496
·
Endokrynol Pol 2009;60(2):134-144.

open access

Vol 60, No 2 (2009)
Reviews — Postgraduate Education
Submitted: 2013-02-15
Published online: 2009-03-27

Abstract

Bone remodeling is essential for skeletal and the whole body health. Imbalance in skeletal turnover, so that bone resorption exceeds bone formation, may lead to reduction in bone strength and increase fractures risk. The main target of anticatabolic therapy is to normalize increased osteoclasts activity and bone turnover. Molecular mechanisms of action of this class of drugs are related with different points in cellular signaling pathways that control osteoclasts differentiation and resorbing activity. These mechanisms are briefly described in our review.

Abstract

Bone remodeling is essential for skeletal and the whole body health. Imbalance in skeletal turnover, so that bone resorption exceeds bone formation, may lead to reduction in bone strength and increase fractures risk. The main target of anticatabolic therapy is to normalize increased osteoclasts activity and bone turnover. Molecular mechanisms of action of this class of drugs are related with different points in cellular signaling pathways that control osteoclasts differentiation and resorbing activity. These mechanisms are briefly described in our review.

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Keywords

mechanism of action; anticatabolic therapy; bone resorption; osteoclast; osteoporosis

About this article
Title

Mechanisms of action of anticatabolic drugs used in osteoporosis therapy

Journal

Endokrynologia Polska

Issue

Vol 60, No 2 (2009)

Article type

Review paper

Pages

134-144

Published online

2009-03-27

Page views

516

Article views/downloads

5665

DOI

10.5603/ep.25496

Bibliographic record

Endokrynol Pol 2009;60(2):134-144.

Keywords

mechanism of action
anticatabolic therapy
bone resorption
osteoclast
osteoporosis

Authors

Edyta Kryśkiewicz
Roman S. Lorenc

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