open access

Vol 60, No 3 (2009)
Original papers
Published online: 2009-04-27
Submitted: 2013-02-15
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Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism

Barbara Rybus-Kalinowska, Krystyna Żwirska-Korczala, Mariusz Kalinowski, Michał Kukla, Ewa Birkner, Jerzy Jochem
Endokrynologia Polska 2009;60(3):199-202.

open access

Vol 60, No 3 (2009)
Original papers
Published online: 2009-04-27
Submitted: 2013-02-15

Abstract


Introduction: The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism.
Material and methods: The study was conducted on 20 females with non-autoimmunological subclinical hyperthyroidism and 15 healthy women. Manganase-containing superoxide dismutase (Mn-SOD) and extracellular superoxide dismutase (EC-SOD) plasma activity, and malondialdehyde (MDA) plasma concentration were measured.
Results: EC-SOD plasma activity was significantly higher in women with subclinical hyperthyroidism when compared with the control group (13.3 ± 2.1 vs. 10.9 ± 1.4 NU/ml; p < 0.05), unlike Mn-SOD (4.2 ± 0.5 vs. 4.0 ± 1.0 NU/ml). MDA plasma concentration increased significantly in women with subclinical hyperthyroidism (3.5 ± 1.2 vs. 2.0 ± 0.6 μmol/l; p < 0.05).
Conclusions: The increased EC-SOD plasma activity may reflect disturbances of oxidative state in subclinical hyperthyroidism. Parallel increase of MDA plasma concentration may indicate enhancement of lipid peroxidationin in patients with subclinical hyperthyroidism.

Abstract


Introduction: The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism.
Material and methods: The study was conducted on 20 females with non-autoimmunological subclinical hyperthyroidism and 15 healthy women. Manganase-containing superoxide dismutase (Mn-SOD) and extracellular superoxide dismutase (EC-SOD) plasma activity, and malondialdehyde (MDA) plasma concentration were measured.
Results: EC-SOD plasma activity was significantly higher in women with subclinical hyperthyroidism when compared with the control group (13.3 ± 2.1 vs. 10.9 ± 1.4 NU/ml; p < 0.05), unlike Mn-SOD (4.2 ± 0.5 vs. 4.0 ± 1.0 NU/ml). MDA plasma concentration increased significantly in women with subclinical hyperthyroidism (3.5 ± 1.2 vs. 2.0 ± 0.6 μmol/l; p < 0.05).
Conclusions: The increased EC-SOD plasma activity may reflect disturbances of oxidative state in subclinical hyperthyroidism. Parallel increase of MDA plasma concentration may indicate enhancement of lipid peroxidationin in patients with subclinical hyperthyroidism.
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Keywords

subclinical hyperthyroidism; oxidative stress; antioxidative enzymes; malondialdehyde

About this article
Title

Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism

Journal

Endokrynologia Polska

Issue

Vol 60, No 3 (2009)

Pages

199-202

Published online

2009-04-27

Bibliographic record

Endokrynologia Polska 2009;60(3):199-202.

Keywords

subclinical hyperthyroidism
oxidative stress
antioxidative enzymes
malondialdehyde

Authors

Barbara Rybus-Kalinowska
Krystyna Żwirska-Korczala
Mariusz Kalinowski
Michał Kukla
Ewa Birkner
Jerzy Jochem

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