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Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism
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Abstract
Introduction: The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism.
Material and methods: The study was conducted on 20 females with non-autoimmunological subclinical hyperthyroidism and 15 healthy women. Manganase-containing superoxide dismutase (Mn-SOD) and extracellular superoxide dismutase (EC-SOD) plasma activity, and malondialdehyde (MDA) plasma concentration were measured.
Results: EC-SOD plasma activity was significantly higher in women with subclinical hyperthyroidism when compared with the control group (13.3 ± 2.1 vs. 10.9 ± 1.4 NU/ml; p < 0.05), unlike Mn-SOD (4.2 ± 0.5 vs. 4.0 ± 1.0 NU/ml). MDA plasma concentration increased significantly in women with subclinical hyperthyroidism (3.5 ± 1.2 vs. 2.0 ± 0.6 μmol/l; p < 0.05).
Conclusions: The increased EC-SOD plasma activity may reflect disturbances of oxidative state in subclinical hyperthyroidism. Parallel increase of MDA plasma concentration may indicate enhancement of lipid peroxidationin in patients with subclinical hyperthyroidism.
Abstract
Introduction: The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism.
Material and methods: The study was conducted on 20 females with non-autoimmunological subclinical hyperthyroidism and 15 healthy women. Manganase-containing superoxide dismutase (Mn-SOD) and extracellular superoxide dismutase (EC-SOD) plasma activity, and malondialdehyde (MDA) plasma concentration were measured.
Results: EC-SOD plasma activity was significantly higher in women with subclinical hyperthyroidism when compared with the control group (13.3 ± 2.1 vs. 10.9 ± 1.4 NU/ml; p < 0.05), unlike Mn-SOD (4.2 ± 0.5 vs. 4.0 ± 1.0 NU/ml). MDA plasma concentration increased significantly in women with subclinical hyperthyroidism (3.5 ± 1.2 vs. 2.0 ± 0.6 μmol/l; p < 0.05).
Conclusions: The increased EC-SOD plasma activity may reflect disturbances of oxidative state in subclinical hyperthyroidism. Parallel increase of MDA plasma concentration may indicate enhancement of lipid peroxidationin in patients with subclinical hyperthyroidism.
Keywords
subclinical hyperthyroidism; oxidative stress; antioxidative enzymes; malondialdehyde
About this articleTitle
Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism
Journal
Issue
Article type
Original paper
Pages
199-202
Published online
2009-04-27
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649
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2095
Bibliographic record
Endokrynol Pol 2009;60(3):199-202.
Keywords
subclinical hyperthyroidism
oxidative stress
antioxidative enzymes
malondialdehyde
Authors
Barbara Rybus-Kalinowska
Krystyna Żwirska-Korczala
Mariusz Kalinowski
Michał Kukla
Ewa Birkner
Jerzy Jochem
