open access

Vol 60, No 4 (2009)
Original papers
Published online: 2009-06-26
Submitted: 2013-02-15
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The incidence of the thyroid microsomal autoantibodies in Alzheimer disease

Paweł Gut, Jerzy Kosowicz, Jolanta Florczak, Katarzyna Ziemnicka, Maciej Bączyk, Jerzy Sowiński, Wojciech Kozubski
Endokrynologia Polska 2009;60(4):271-277.

open access

Vol 60, No 4 (2009)
Original papers
Published online: 2009-06-26
Submitted: 2013-02-15

Abstract


Background: Alzheimer disease is associated with degeneration of brain by deposition of β-A4 amyloid protein. Above protein is a product of amyloid protein precursor proteolysis. This protein is coded by chromosom 21 together with histocompatibility antigens on surface of thyroid follicle. Until now the study suggest coexistence of autoimmune thyroid disease and Alzheimer disease. The aim of the study was evaluation of thyroid autoantibodies in Alzheimer disease.
Material and methods: Study were performed in 34 Alzheimer disease patients. Sera of control subjects were obtained from 20 patients with vascular dementia. Incidence of thyroid autoantibodies was assessed by polyacrylamide electrophoresis gel and western-blotting. Thyroid microsomes were obtained from human thyroid tissues by ultracentrifugation and solubilization in 1% desoxycholic acid.
Results: In 21 sera from 34 we detected autoantibodies against thyroid microsomal antigens reacting with 91 kDa antigen. 16 sera were reacting with 97 kDa, 13 sera with 55 kDa, and 7 sera with 67 kDa proteins.
Conclusions: In sera of Alzheimer disease patients autoantibodies against thyroid microsomal antigens can be frequently detected. The most frequent are antibodies against 91 kDa. It is important to note that Alzheimer disease patients should be screen for thyroid hormones.

Abstract


Background: Alzheimer disease is associated with degeneration of brain by deposition of β-A4 amyloid protein. Above protein is a product of amyloid protein precursor proteolysis. This protein is coded by chromosom 21 together with histocompatibility antigens on surface of thyroid follicle. Until now the study suggest coexistence of autoimmune thyroid disease and Alzheimer disease. The aim of the study was evaluation of thyroid autoantibodies in Alzheimer disease.
Material and methods: Study were performed in 34 Alzheimer disease patients. Sera of control subjects were obtained from 20 patients with vascular dementia. Incidence of thyroid autoantibodies was assessed by polyacrylamide electrophoresis gel and western-blotting. Thyroid microsomes were obtained from human thyroid tissues by ultracentrifugation and solubilization in 1% desoxycholic acid.
Results: In 21 sera from 34 we detected autoantibodies against thyroid microsomal antigens reacting with 91 kDa antigen. 16 sera were reacting with 97 kDa, 13 sera with 55 kDa, and 7 sera with 67 kDa proteins.
Conclusions: In sera of Alzheimer disease patients autoantibodies against thyroid microsomal antigens can be frequently detected. The most frequent are antibodies against 91 kDa. It is important to note that Alzheimer disease patients should be screen for thyroid hormones.
Get Citation

Keywords

Alzheimer disease; thyroid autoimmune disease; thyroid autoantibodies

About this article
Title

The incidence of the thyroid microsomal autoantibodies in Alzheimer disease

Journal

Endokrynologia Polska

Issue

Vol 60, No 4 (2009)

Pages

271-277

Published online

2009-06-26

Bibliographic record

Endokrynologia Polska 2009;60(4):271-277.

Keywords

Alzheimer disease
thyroid autoimmune disease
thyroid autoantibodies

Authors

Paweł Gut
Jerzy Kosowicz
Jolanta Florczak
Katarzyna Ziemnicka
Maciej Bączyk
Jerzy Sowiński
Wojciech Kozubski

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